Gene Information
|
Gene Name
|
MYD88 |
|
Gene ID
|
4615
|
|
Gene Full Name
|
MYD88 innate immune signal transduction adaptor |
|
Gene Alias
|
IMD68|MYD88D|WM1 |
|
Transcripts
|
ENSG00000172936
|
|
Virus
|
CHIKV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Cytosol;Vesicles, Mitochondria; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
|
Uniport_ID
|
Q99836
|
|
HGNC ID
|
HGNC:7562
|
|
OMIM ID
|
602170 |
|
Summary
|
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
Target gene [MYD88] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
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CHIKV Target gene Detail Information
