Gene Name	PIK3C2B
Gene ID	5287
Gene Full Name	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Gene Alias	C2-PI3K
Transcripts	ENSG00000133056
Virus	XMRV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Nuclear membrane;Cytosol;
Membrane Info	Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Uniport_ID	O00750
HGNC ID	HGNC:8972
OMIM ID	602838
Summary	The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
8000018	chr1	21	6	0	27	View