Gene Name	PTK2
Gene ID	5747
Gene Full Name	protein tyrosine kinase 2
Gene Alias	FADK|FADK 1|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK
Transcripts	ENSG00000169398
Virus	RABV
Gene Type	protein-coding
HPA Location Info	Focal adhesion sites;Vesicles, Primary cilium, Primary cilium tip, Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q05397
HGNC ID	HGNC:9611
OMIM ID	600758
Summary	This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	25410852	R109A	P	P	Cell line	T	View