Gene Information
|
Gene Name
|
STAT1 |
|
Gene ID
|
6772
|
|
Gene Full Name
|
signal transducer and activator of transcription 1 |
|
Gene Alias
|
CANDF7|IMD31A|IMD31B|IMD31C|ISGF-3|STAT91 |
|
Transcripts
|
ENSG00000115415
|
|
Virus
|
RABV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm, Cytosol; 
|
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Membrane Info
|
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
P42224
|
|
HGNC ID
|
HGNC:11362
|
|
OMIM ID
|
600555 |
|
Summary
|
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020] |
Target gene [STAT1] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
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RABV Target gene Detail Information
