Gene Name	TES
Gene ID	26136
Gene Full Name	testin LIM domain protein
Gene Alias	TESS|TESS-2
Transcripts	ENSG00000135269
Virus	XMRV
Gene Type	protein-coding
HPA Location Info	Focal adhesion sites, Cytosol;Plasma membrane, Cell Junctions;
Membrane Info	Predicted intracellular proteins
Uniport_ID	Q9UGI8
HGNC ID	HGNC:14620
OMIM ID	606085
Summary	Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Aug 2023]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
8000039	chr7	2936	1596	1150	5682	View