Gene Information
|
Gene Name
|
TICAM1 |
|
Gene ID
|
148022
|
|
Gene Full Name
|
TIR domain containing adaptor molecule 1 |
|
Gene Alias
|
IIAE6|MyD88-3|PRVTIRB|TICAM-1|TRIF |
|
Transcripts
|
ENSG00000127666
|
|
Virus
|
CHIKV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm, Nucleoli;Plasma membrane; 
|
|
Membrane Info
|
Disease related genes, Human disease related genes, Predicted intracellular proteins |
|
Uniport_ID
|
Q8IUC6
|
|
HGNC ID
|
HGNC:18348
|
|
OMIM ID
|
607601 |
|
Summary
|
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020] |
Target gene [TICAM1] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
|
|
CHIKV Target gene Detail Information
