Gene Information
|
Gene Name
|
TLR7 |
|
Gene ID
|
51284
|
|
Gene Full Name
|
toll like receptor 7 |
|
Gene Alias
|
IMD74|SLEB17|TLR7-like |
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Transcripts
|
ENSG00000196664
|
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Virus
|
CHIKV |
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Gene Type
|
protein-coding |
|
HPA Location Info
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Membrane Info
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Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins |
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Uniport_ID
|
Q9NYK1
|
|
HGNC ID
|
HGNC:15631
|
|
OMIM ID
|
300365 |
|
Summary
|
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020] |
Target gene [TLR7] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
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CHIKV Target gene Detail Information
