Gene symbol: Myh7b

Organism: Rattus norvegicus

Summary: Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Involved in regulation of CAMKK-AMPK signaling cascade and regulation of cytosolic calcium ion concentration. Predicted to be located in cardiac myofibril. Predicted to be part of myosin complex. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human MYH7B (myosin heavy chain 7B). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 311570 Ensembl:ENSRNOG00000018997 AllianceGenome:RGD:1307994


GO Annotation


Category Term ID Term description
Process GO:0006873 Cellular ion homeostasis
Process GO:0006874 Cellular calcium ion homeostasis
Process GO:0006875 Cellular metal ion homeostasis
Process GO:0009966 Regulation of signal transduction
Process GO:0009987 Cellular process
Process GO:0010646 Regulation of cell communication
Process GO:0019725 Cellular homeostasis
Process GO:0023051 Regulation of signaling
Process GO:0030003 Cellular cation homeostasis
Process GO:0032502 Developmental process
Process GO:0042592 Homeostatic process
Process GO:0048583 Regulation of response to stimulus
Process GO:0048878 Chemical homeostasis
Process GO:0050789 Regulation of biological process
Process GO:0050794 Regulation of cellular process
Process GO:0050801 Ion homeostasis
Process GO:0050848 Regulation of calcium-mediated signaling
Process GO:0051480 Regulation of cytosolic calcium ion concentration
Process GO:0055065 Metal ion homeostasis
Process GO:0055074 Calcium ion homeostasis
Process GO:0055080 Cation homeostasis
Process GO:0055082 Cellular chemical homeostasis
Process GO:0065007 Biological regulation
Process GO:0065008 Regulation of biological quality
Process GO:0072503 Cellular divalent inorganic cation homeostasis
Process GO:0072507 Divalent inorganic cation homeostasis
Process GO:0098771 Inorganic ion homeostasis
Process GO:1902531 Regulation of intracellular signal transduction
Process GO:1905289 Regulation of CAMKK-AMPK signaling cascade
Component GO:0005622 Intracellular anatomical structure
Component GO:0005737 Cytoplasm
Component GO:0005856 Cytoskeleton
Component GO:0015629 Actin cytoskeleton
Component GO:0016459 Myosin complex
Component GO:0016460 Myosin II complex
Component GO:0030016 Myofibril
Component GO:0032982 Myosin filament
Component GO:0032991 Protein-containing complex
Component GO:0043226 Organelle
Component GO:0043228 Non-membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043232 Intracellular non-membrane-bounded organelle
Component GO:0043292 Contractile fiber
Component GO:0097512 Cardiac myofibril
Component GO:0099080 Supramolecular complex
Component GO:0099081 Supramolecular polymer
Component GO:0099512 Supramolecular fiber
Component GO:0110165 Cellular anatomical entity
Function GO:0000146 Microfilament motor activity
Function GO:0000166 Nucleotide binding
Function GO:0003774 Cytoskeletal motor activity
Function GO:0003779 Actin binding
Function GO:0005488 Binding
Function GO:0005515 Protein binding
Function GO:0005524 ATP binding
Function GO:0008092 Cytoskeletal protein binding
Function GO:0017076 Purine nucleotide binding
Function GO:0030554 Adenyl nucleotide binding
Function GO:0032553 Ribonucleotide binding
Function GO:0032555 Purine ribonucleotide binding
Function GO:0032559 Adenyl ribonucleotide binding
Function GO:0035639 Purine ribonucleoside triphosphate binding
Function GO:0036094 Small molecule binding
Function GO:0043167 Ion binding
Function GO:0043168 Anion binding
Function GO:0044877 Protein-containing complex binding
Function GO:0051015 Actin filament binding
Function GO:0097159 Organic cyclic compound binding
Function GO:0097367 Carbohydrate derivative binding
Function GO:0140657 ATP-dependent activity
Function GO:1901265 Nucleoside phosphate binding
Function GO:1901363 Heterocyclic compound binding

Pathway annotation


Category Term ID Term description
KEGG rno04814 Motor proteins
KEGG rno04820 Cytoskeleton in muscle cells

Expression profile of Myh7b in omics data



ID GSE100499
Title Exploring acupuncture mechanism in preconditioning of IRI
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM2685201 MX1 tissue: Myocardium gender: male 10.21995
GSM2685202 MX2 tissue: Myocardium gender: female 10.465094
GSM2685203 MX3 tissue: Myocardium gender: female 10.230768
GSM2685204 MX4 tissue: Myocardium gender: male 10.095587
GSM2685205 DZ1 tissue: Myocardium gender: male 9.775183
GSM2685206 DZ2 tissue: Myocardium gender: male 9.992899
GSM2685207 DZ3 tissue: Myocardium gender: female 10.26892
GSM2685208 DZ4 tissue: Myocardium gender: female 9.942701
GSM2685209 JJ1 tissue: Myocardium gender: male 10.214993
GSM2685210 JJ2 tissue: Myocardium gender: female 9.528324
GSM2685211 JJ3 tissue: Myocardium gender: female 9.872156
GSM2685212 JJ4 tissue: Myocardium gender: male 8.77432
GSM2685213 NG1 tissue: Myocardium gender: male 9.771388
GSM2685214 NG2 tissue: Myocardium gender: female 9.584005
GSM2685215 NG3 tissue: Myocardium gender: male 9.303994
GSM2685216 NG4 tissue: Myocardium gender: female 9.598562
GSM2685217 YL1 tissue: Myocardium gender: male 10.111709
GSM2685218 YL2 tissue: Myocardium gender: male 9.906652
GSM2685219 YL3 tissue: Myocardium gender: female 10.79486
GSM2685220 YL4 tissue: Myocardium gender: female 10.767324
GSM2685221 QC1 tissue: Myocardium gender: male 10.553924
GSM2685222 QC2 tissue: Myocardium gender: male 10.756778
GSM2685223 QC3 tissue: Myocardium gender: female 10.367016
GSM2685224 QC4 tissue: Myocardium gender: female 9.885184

ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 4.136981516
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 4.033124967
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 4.016275616
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 4.029567995
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 4.147349543
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 4.110117947

ID GSE138454
Title Impact of inflammation on hepatic subcellular energetics in anesthetized rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4108997 Sample 1 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 8.0
GSM4108998 Sample 2 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 5.0
GSM4108999 Sample 3 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 5.0
GSM4109000 Sample 4 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 7.0
GSM4109001 Sample 5 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 15.0
GSM4109002 Sample 6 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 9.0
GSM4109003 Sample 7 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 11.0
GSM4109004 Sample 8 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 19.0
GSM4109005 Sample9 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 8.0
GSM4109006 Sample10 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 5.0
GSM4109007 Sample11 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 4.0
GSM4109008 Sample12 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 13.0
GSM4109009 Sample13 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 9.0
GSM4109010 Sample14 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 10.0
GSM4109011 Sample 15 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 29.0
GSM4109012 Sample16 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 12.0

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 6.045506
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 6.180823
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 6.149748
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 6.44219
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 6.062704
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.978288

ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 1.367
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 1.269
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 1.387
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 1.524
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 1.517

ID GSE192399
Title Gene expression of brain regions activated by sevoflurane and propofol
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5746332 LHb, Sevoflurane, 60mins brain region: the lateral habenula (LHb) treatment: Sevoflurane 4.21229
GSM5746333 LHb, O2, 60mins brain region: the lateral habenula (LHb) treatment: O2 3.89508
GSM5746334 MHb, Sevoflurane, 60mins brain region: the medial habenula (MHb) treatment: Sevoflurane 4.04207
GSM5746335 MHb, O2, 60mins brain region: the medial habenula (MHb) treatment: O2 3.82245
GSM5746336 Sol, Sevoflurane, 60mins brain region: the solitary nucleus (Sol) treatment: Sevoflurane 3.77739
GSM5746337 Sol, O2, 60mins brain region: the solitary nucleus (Sol) treatment: O2 3.85763
GSM5746338 Mve, Sevoflurane, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane 3.85006
GSM5746339 Mve, O2, 60mins brain region: the medial vestibular nucleus (MVe) treatment: O2 4.07852
GSM5746340 LHb, Propofol, 60mins brain region: the lateral habenula (LHb) treatment: Propofol 3.87938
GSM5746341 LHb, Intralipos, 60mins brain region: the lateral habenula (LHb) treatment: Intralipos 3.84692
GSM5746342 MHb, Propofol, 60mins brain region: the medial habenula (MHb) treatment: Propofol 3.64806
GSM5746343 MHb, Intralipos, 60mins brain region: the medial habenula (MHb) treatment: Intralipos 3.60408
GSM5746344 Sol, Propofol, 60mins brain region: the solitary nucleus (Sol) treatment: Propofol 3.66765
GSM5746345 Sol, Intralipos, 60mins brain region: the solitary nucleus (Sol) treatment: Intralipos 3.71508
GSM5746346 MVe, Propofol, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Propofol 3.84561
GSM5746347 MVe, Intralipos, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Intralipos 3.63804

ID GSE232804
Title EGR3 regulates opioid-related nociception and motivation in male rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7383519 ww01_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 19.0
GSM7383520 ww02_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 19.0
GSM7383521 ww03_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 29.0
GSM7383522 ww05_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 22.0
GSM7383523 ww06_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 32.0
GSM7383524 ww07_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 29.0
GSM7383525 ww08_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 17.0
GSM7383526 ww10_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 24.0
GSM7383527 ww12_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 30.0
GSM7383528 ww13_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 27.0
GSM7383529 ww14_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 27.0
GSM7383530 ww15_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 23.0
GSM7383531 ww16_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 32.0
GSM7383532 ww17_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 30.0
GSM7383533 ww18_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 23.0
GSM7383534 ww20_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 13.0
GSM7383535 ww21_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 26.0
GSM7383536 ww22_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 17.0
GSM7383537 ww23_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 20.0
GSM7383538 ww24_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 26.0
GSM7383539 ww26_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 19.0
GSM7383540 ww27_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 34.0
GSM7383541 ww28_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 29.0
GSM7383542 ww30_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 35.0
GSM7383543 ww31_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 30.0
GSM7383544 ww32_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 32.0
GSM7383545 ww34_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 20.0
GSM7383546 ww35_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 17.0
GSM7383547 ww36_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 28.0
GSM7383548 ww37_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 28.0
GSM7383549 ww38_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 21.0
GSM7383550 www09_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 27.0
GSM7383551 www19_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 26.0
GSM7383552 www29_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 39.0
GSM7383553 www33_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 26.0
GSM7383554 www39_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 23.0

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 0.605849
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 0.66
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 0.717622
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 0.804955

ID GSE2982
Title Effect of inhaled anesthetic to cultured cortical neurons
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM61779 Cell Culture Exposure (control1) Cy3 label;Cy5; -0.173
GSM61796 Cell Culture Exposure (control2) Cy3; Cy5 0.0271
GSM61797 Cell Culture Exposure (control3) Cy3; Cy5 0.0
GSM61798 Cell Culture Exposure (1MAC Halo1) Cy3; Cy5 0.36
GSM61799 Cell Culture Exposure (1MAC Halo2) Cy3; Cy5 -0.0865
GSM61800 Cell Culture Exposure (1MAC Halo3) Cy3; Cy5 -0.0739
GSM61801 Cell Culture Exposure (3MAC Halo1) Cy3; Cy5 -0.135
GSM61802 Cell Culture Exposure (3MAC Halo2) Cy3; Cy5 -0.188
GSM61803 Cell Culture Exposure (3MAC Halo3) Cy3; Cy5 0.0776
GSM61804 Cell Culture Exposure (3MAC ISO1) Cy3; Cy5 -0.0664
GSM61805 Cell Culture Exposure (3MAC ISO2) Cy3; Cy5 0.168
GSM61806 Cell Culture Exposure (3MAC ISO3) Cy3; Cy5 -0.0616

ID GSE53897
Title Genome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1303240 DRG RVM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.991829
GSM1303241 DRG RVM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.006985
GSM1303242 DRG RVM3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.095449
GSM1303243 DRG RVM7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.018274
GSM1303244 DRG RVOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.17644
GSM1303245 DRG RVOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.199671
GSM1303246 DRG RVOx5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.071101
GSM1303247 DRG RVOx7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.512145
GSM1303248 DRG RVS4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.954153
GSM1303249 DRG RVS5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.11182
GSM1303250 DRG RVS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.154064
GSM1303251 DRG RVS7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.000394
GSM1303252 DRG RSM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.956559
GSM1303253 DRG RSM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.885671
GSM1303254 DRG RSM4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.951699
GSM1303255 DRG RSM5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.845315
GSM1303256 DRG RSOx1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.981591
GSM1303257 DRG RSOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.945123
GSM1303258 DRG RSOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.879192
GSM1303259 DRG RSOx4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.881051
GSM1303260 DRG RSS1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.067386
GSM1303261 DRG RSS2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.952802
GSM1303262 DRG RSS3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.200126
GSM1303263 DRG RSS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.094972

ID GSE55573
Title Using DNA microarray to screen intracellular signal pathways of hypoglycemic activity by electroacupuncture of Zusanli (ST36) acupoints in streptozotocin-induced rats with diabetes
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1339443 Mock skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 107.0591
GSM1339444 EA (electroacupuncture) skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 123.1505