Acupuncture anesthesia

Gene symbol: Mt2A

Also known as: Mt2; MT-2; MT-II

Organism: Rattus norvegicus

Summary: Enables cadmium ion binding activity and zinc ion binding activity. Involved in astrocyte activation. Predicted to be located in cytoplasm and nucleus. Biomarker of Alzheimer's disease; kidney failure; median neuropathy; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in carotid stenosis and type 2 diabetes mellitus. Orthologous to several human genes including MT1E (metallothionein 1E); MT1F (metallothionein 1F); and MT1X (metallothionein 1X). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 689415 Ensembl:ENSRNOG00000043098 AllianceGenome:RGD:1592345

GO Annotation

Category	Term ID	Term description
Process	GO:0001775	Cell activation
Process	GO:0006873	Cellular ion homeostasis
Process	GO:0006875	Cellular metal ion homeostasis
Process	GO:0006882	Cellular zinc ion homeostasis
Process	GO:0006950	Response to stress
Process	GO:0006952	Defense response
Process	GO:0006954	Inflammatory response
Process	GO:0007154	Cell communication
Process	GO:0007165	Signal transduction
Process	GO:0007263	Nitric oxide mediated signal transduction
Process	GO:0007275	Multicellular organism development
Process	GO:0007399	Nervous system development
Process	GO:0007417	Central nervous system development
Process	GO:0009605	Response to external stimulus
Process	GO:0009607	Response to biotic stimulus
Process	GO:0009617	Response to bacterium
Process	GO:0009636	Response to toxic substance
Process	GO:0009987	Cellular process
Process	GO:0010001	Glial cell differentiation
Process	GO:0010033	Response to organic substance
Process	GO:0010035	Response to inorganic substance
Process	GO:0010038	Response to metal ion
Process	GO:0010043	Response to zinc ion
Process	GO:0010273	Detoxification of copper ion
Process	GO:0014002	Astrocyte development
Process	GO:0019725	Cellular homeostasis
Process	GO:0019932	Second-messenger-mediated signaling
Process	GO:0021782	Glial cell development
Process	GO:0022008	Neurogenesis
Process	GO:0023052	Signaling
Process	GO:0030003	Cellular cation homeostasis
Process	GO:0030154	Cell differentiation
Process	GO:0032501	Multicellular organismal process
Process	GO:0032502	Developmental process
Process	GO:0034097	Response to cytokine
Process	GO:0035556	Intracellular signal transduction
Process	GO:0036015	Response to interleukin-3
Process	GO:0036016	Cellular response to interleukin-3
Process	GO:0036017	Response to erythropoietin
Process	GO:0036018	Cellular response to erythropoietin
Process	GO:0040008	Regulation of growth
Process	GO:0042063	Gliogenesis
Process	GO:0042221	Response to chemical
Process	GO:0042592	Homeostatic process
Process	GO:0043207	Response to external biotic stimulus
Process	GO:0044419	Biological process involved in interspecies interaction between organisms
Process	GO:0045926	Negative regulation of growth
Process	GO:0046686	Response to cadmium ion
Process	GO:0046688	Response to copper ion
Process	GO:0046916	Cellular transition metal ion homeostasis
Process	GO:0048143	Astrocyte activation
Process	GO:0048468	Cell development
Process	GO:0048519	Negative regulation of biological process
Process	GO:0048708	Astrocyte differentiation
Process	GO:0048731	System development
Process	GO:0048856	Anatomical structure development
Process	GO:0048869	Cellular developmental process
Process	GO:0048878	Chemical homeostasis
Process	GO:0050789	Regulation of biological process
Process	GO:0050794	Regulation of cellular process
Process	GO:0050801	Ion homeostasis
Process	GO:0050896	Response to stimulus
Process	GO:0051707	Response to other organism
Process	GO:0051716	Cellular response to stimulus
Process	GO:0055065	Metal ion homeostasis
Process	GO:0055069	Zinc ion homeostasis
Process	GO:0055076	Transition metal ion homeostasis
Process	GO:0055080	Cation homeostasis
Process	GO:0055082	Cellular chemical homeostasis
Process	GO:0061687	Detoxification of inorganic compound
Process	GO:0061900	Glial cell activation
Process	GO:0065007	Biological regulation
Process	GO:0065008	Regulation of biological quality
Process	GO:0070887	Cellular response to chemical stimulus
Process	GO:0071241	Cellular response to inorganic substance
Process	GO:0071248	Cellular response to metal ion
Process	GO:0071276	Cellular response to cadmium ion
Process	GO:0071280	Cellular response to copper ion
Process	GO:0071294	Cellular response to zinc ion
Process	GO:0071310	Cellular response to organic substance
Process	GO:0071345	Cellular response to cytokine stimulus
Process	GO:0072503	Cellular divalent inorganic cation homeostasis
Process	GO:0072507	Divalent inorganic cation homeostasis
Process	GO:0097501	Stress response to metal ion
Process	GO:0098754	Detoxification
Process	GO:0098771	Inorganic ion homeostasis
Process	GO:0150076	Neuroinflammatory response
Process	GO:1990169	Stress response to copper ion
Component	GO:0005622	Intracellular anatomical structure
Component	GO:0005634	Nucleus
Component	GO:0005737	Cytoplasm
Component	GO:0043226	Organelle
Component	GO:0043227	Membrane-bounded organelle
Component	GO:0043229	Intracellular organelle
Component	GO:0043231	Intracellular membrane-bounded organelle
Component	GO:0110165	Cellular anatomical entity
Function	GO:0005488	Binding
Function	GO:0008270	Zinc ion binding
Function	GO:0043167	Ion binding
Function	GO:0043169	Cation binding
Function	GO:0046870	Cadmium ion binding
Function	GO:0046872	Metal ion binding
Function	GO:0046914	Transition metal ion binding

Pathway annotation

Category	Term ID	Term description
RCTM	RNO-5660526	Response to metal ions
RCTM	RNO-5661231	Metallothioneins bind metals
RCTM	RNO-8953897	Cellular responses to stimuli
KEGG	rno04978	Mineral absorption

Expression profile of Mt2A in omics data

ID	GSE100499
Title	Exploring acupuncture mechanism in preconditioning of IRI
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM2685201	MX1	tissue: Myocardium gender: male	11.9091605
GSM2685202	MX2	tissue: Myocardium gender: female	11.363295749999999
GSM2685203	MX3	tissue: Myocardium gender: female	11.681236
GSM2685204	MX4	tissue: Myocardium gender: male	11.61672675
GSM2685205	DZ1	tissue: Myocardium gender: male	12.272238
GSM2685206	DZ2	tissue: Myocardium gender: male	10.775205
GSM2685207	DZ3	tissue: Myocardium gender: female	9.850219
GSM2685208	DZ4	tissue: Myocardium gender: female	11.1723825
GSM2685209	JJ1	tissue: Myocardium gender: male	11.937603
GSM2685210	JJ2	tissue: Myocardium gender: female	11.277994
GSM2685211	JJ3	tissue: Myocardium gender: female	11.9377335
GSM2685212	JJ4	tissue: Myocardium gender: male	12.87887175
GSM2685213	NG1	tissue: Myocardium gender: male	12.445383
GSM2685214	NG2	tissue: Myocardium gender: female	12.037564499999998
GSM2685215	NG3	tissue: Myocardium gender: male	12.571003000000001
GSM2685216	NG4	tissue: Myocardium gender: female	12.403235
GSM2685217	YL1	tissue: Myocardium gender: male	11.598383
GSM2685218	YL2	tissue: Myocardium gender: male	12.496927
GSM2685219	YL3	tissue: Myocardium gender: female	11.308100499999998
GSM2685220	YL4	tissue: Myocardium gender: female	11.557652000000001
GSM2685221	QC1	tissue: Myocardium gender: male	11.590335
GSM2685222	QC2	tissue: Myocardium gender: male	11.178390499999999
GSM2685223	QC3	tissue: Myocardium gender: female	11.3464455
GSM2685224	QC4	tissue: Myocardium gender: female	11.9176

ID	GSE138454
Title	Impact of inflammation on hepatic subcellular energetics in anesthetized rats
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM4108997	Sample 1 Isoflurane sepsis	anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male	98605.0
GSM4108998	Sample 2 Isoflurane sepsis	anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male	80270.0
GSM4108999	Sample 3 Isoflurane sepsis	anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male	100284.0
GSM4109000	Sample 4 Isoflurane sepsis	anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male	72198.0
GSM4109001	Sample 5 Isoflurane control	anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male	78731.0
GSM4109002	Sample 6 Isoflurane control	anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male	74050.0
GSM4109003	Sample 7 Isoflurane control	anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male	80127.0
GSM4109004	Sample 8 Isoflurane control	anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male	169296.0
GSM4109005	Sample9 Propofol sepsis	anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male	65533.0
GSM4109006	Sample10 Propofol sepsis	anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male	75854.0
GSM4109007	Sample11 Propofol sepsis	anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male	83106.0
GSM4109008	Sample12 Propofol sepsis	anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male	146660.0
GSM4109009	Sample13 Propofol control	anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male	34969.0
GSM4109010	Sample14 Propofol control	anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male	32729.0
GSM4109011	Sample 15 Propofol control	anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male	41542.0
GSM4109012	Sample16 Propofol control	anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male	56041.0

ID	GSE139220
Title	Expression data from sevoflurane anesthesia treated rat
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM4134285	Brain_Control_rep1	strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus	10.76283
GSM4134286	Brain_Control_rep2	strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus	10.81446
GSM4134287	Brain_Control_rep3	strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus	10.80332
GSM4134288	Brain_Sevoflurane_rep1	strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus	11.44418
GSM4134289	Brain_Sevoflurane_rep2	strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus	11.65936
GSM4134290	Brain_Sevoflurane_rep3	strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus	11.68779

ID	GSE143895
Title	GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM4276356	dhsc01	strain: Sprague Dawley tissue: DHSC treatment: CCI	177.631
GSM4276357	dhsc03	strain: Sprague Dawley tissue: DHSC treatment: CCI	84.329
GSM4276358	dhsc05	strain: Sprague Dawley tissue: DHSC treatment: CCI	128.914
GSM4276359	dhsc13	strain: Sprague Dawley tissue: DHSC treatment: SHAM	38.931
GSM4276360	dhsc15	strain: Sprague Dawley tissue: DHSC treatment: SHAM	46.769

ID	GSE157924
Title	Regulation of acupuncture on genes in brain stem
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM4780973	Rattus_JSSZ(Sham)	tissue: Rattus brainstem of modeling treatment: Sham	10.51424975
GSM4780974	Rattus_JXZ(Hand Acu)	tissue: Rattus brainstem of modeling treatment: Hand Acu	10.36735926
GSM4780975	Rattus_MXZ(TBI)	tissue: Rattus brainstem of modeling treatment: TBI	10.95804639

ID	GSE1779
Title	Effect of Isoflurane and LTM on basolateral amygdala
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM30790	baseline control 01	male, 275-300g	1426.7
GSM30791	baseline control 02	male, 275-300g	825.4
GSM30792	baseline control 03	male, 275-300g	1446.5
GSM30793	baseline control 04	male, 275-300g	1495.6
GSM30794	baseline control 05	male, 275-300g	1238.6
GSM30795	baseline control 06	male, 275-300g	1003.4
GSM30796	baseline control 07	male, 275-300g	1421.8
GSM30797	baseline control 08	male, 275-300g	1348.3
GSM30798	baseline control 09	male, 275-300g	1364.1
GSM30799	pain 01		1822.8
GSM30800	pain 02		1238.0
GSM30801	pain 03		1252.8
GSM30802	pain 04		1086.7
GSM30803	pain 05		1177.3
GSM30804	FC 01		2131.1
GSM30805	FC 02		1625.3
GSM30806	FC 03		1563.3
GSM30807	FC 04		1383.1
GSM30808	FC 05		1121.0
GSM30809	IFC 01		1604.4
GSM30810	IFC 02		1669.8
GSM30811	IFC 03		1230.9
GSM30812	IFC 04		1446.5
GSM30813	IFC 05		1561.9
GSM99800	isoflurane 01	male, 275-300g	1536.5
GSM99801	isoflurane 02	male, 275-300g	1942.6
GSM99802	isoflurane 03	male, 275-300g	1771.3
GSM99803	isoflurane 04	male, 275-300g	2356.7
GSM99804	isoflurane 05	male, 275-300g	1510.4

ID	GSE190472
Title	Study on VEGF regulation mechanism of acupuncture improving endometrial receptivity in IVF-ET
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM5724271	model 21	Sex: female tissue: Uterine tissue condition: model	1661.0708
GSM5724272	model 22	Sex: female tissue: Uterine tissue condition: model	1053.2107
GSM5724273	model 23	Sex: female tissue: Uterine tissue condition: model	1916.5257
GSM5724274	treatment31	Sex: female tissue: Uterine tissue condition: treatment	2346.7129
GSM5724275	treatment32	Sex: female tissue: Uterine tissue condition: treatment	3003.9125
GSM5724276	treatment33	Sex: female tissue: Uterine tissue condition: treatment	2513.1992
GSM5724277	control 41	Sex: female tissue: Uterine tissue condition: control	422.8598
GSM5724278	control 42	Sex: female tissue: Uterine tissue condition: control	475.6865
GSM5724279	control 43	Sex: female tissue: Uterine tissue condition: control	2092.8417

ID	GSE192399
Title	Gene expression of brain regions activated by sevoflurane and propofol
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM5746332	LHb, Sevoflurane, 60mins	brain region: the lateral habenula (LHb) treatment: Sevoflurane	13.8996
GSM5746333	LHb, O2, 60mins	brain region: the lateral habenula (LHb) treatment: O2	12.5726
GSM5746334	MHb, Sevoflurane, 60mins	brain region: the medial habenula (MHb) treatment: Sevoflurane	13.3779
GSM5746335	MHb, O2, 60mins	brain region: the medial habenula (MHb) treatment: O2	12.9311
GSM5746336	Sol, Sevoflurane, 60mins	brain region: the solitary nucleus (Sol) treatment: Sevoflurane	14.4523
GSM5746337	Sol, O2, 60mins	brain region: the solitary nucleus (Sol) treatment: O2	13.9962
GSM5746338	Mve, Sevoflurane, 60mins	brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane	13.4397
GSM5746339	Mve, O2, 60mins	brain region: the medial vestibular nucleus (MVe) treatment: O2	13.5141
GSM5746340	LHb, Propofol, 60mins	brain region: the lateral habenula (LHb) treatment: Propofol	12.4
GSM5746341	LHb, Intralipos, 60mins	brain region: the lateral habenula (LHb) treatment: Intralipos	12.6711
GSM5746342	MHb, Propofol, 60mins	brain region: the medial habenula (MHb) treatment: Propofol	12.3875
GSM5746343	MHb, Intralipos, 60mins	brain region: the medial habenula (MHb) treatment: Intralipos	12.7293
GSM5746344	Sol, Propofol, 60mins	brain region: the solitary nucleus (Sol) treatment: Propofol	14.2509
GSM5746345	Sol, Intralipos, 60mins	brain region: the solitary nucleus (Sol) treatment: Intralipos	14.5415
GSM5746346	MVe, Propofol, 60mins	brain region: the medial vestibular nucleus (MVe) treatment: Propofol	13.8429
GSM5746347	MVe, Intralipos, 60mins	brain region: the medial vestibular nucleus (MVe) treatment: Intralipos	14.2863

ID	GSE232804
Title	EGR3 regulates opioid-related nociception and motivation in male rats
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM7383519	ww01_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Salin	83.0
GSM7383520	ww02_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Saline	100.0
GSM7383521	ww03_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Salin	75.0
GSM7383522	ww05_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Saline	88.0
GSM7383523	ww06_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Salin	86.0
GSM7383524	ww07_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Saline	70.0
GSM7383525	ww08_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Salin	68.0
GSM7383526	ww10_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Saline	83.0
GSM7383527	ww12_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	46.0
GSM7383528	ww13_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	111.0
GSM7383529	ww14_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	84.0
GSM7383530	ww15_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	69.0
GSM7383531	ww16_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	115.0
GSM7383532	ww17_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	131.0
GSM7383533	ww18_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	70.0
GSM7383534	ww20_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	60.0
GSM7383535	ww21_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	102.0
GSM7383536	ww22_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	76.0
GSM7383537	ww23_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	62.0
GSM7383538	ww24_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	85.0
GSM7383539	ww26_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	69.0
GSM7383540	ww27_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	146.0
GSM7383541	ww28_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	126.0
GSM7383542	ww30_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	105.0
GSM7383543	ww31_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	84.0
GSM7383544	ww32_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	59.0
GSM7383545	ww34_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	120.0
GSM7383546	ww35_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	104.0
GSM7383547	ww36_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	70.0
GSM7383548	ww37_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	92.0
GSM7383549	ww38_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	92.0
GSM7383550	www09_Saline_Saline	tissue: Brain / mPFC pain: Saline drug: Saline	121.0
GSM7383551	www19_Saline_OXY	tissue: Brain / mPFC pain: Saline drug: OXY	126.0
GSM7383552	www29_CFA_Saline	tissue: Brain / mPFC pain: CFA drug: Saline	96.0
GSM7383553	www33_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	101.0
GSM7383554	www39_CFA_OXY	tissue: Brain / mPFC pain: CFA drug: OXY	45.0

ID	GSE244436
Title	Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM7816143	Liver, Control for SevoAnes	tissue: liver genotype: wild type treatment: Control for SevoAnes	1245.222778
GSM7816144	Liver, Anesthetized with sevoflurane for 6 h	tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h	1423.546143
GSM7816145	Liver, Control for DesAnes	tissue: liver genotype: wild type treatment: Control for DesAnes	455.096039
GSM7816146	Liver, Anesthetized with desflurane for 6 h	tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h	1582.550415

ID	GSE2982
Title	Effect of inhaled anesthetic to cultured cortical neurons
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM61779	Cell Culture Exposure (control1)	Cy3 label;Cy5;	0.122
GSM61796	Cell Culture Exposure (control2)	Cy3; Cy5	-0.719
GSM61797	Cell Culture Exposure (control3)	Cy3; Cy5	0.315
GSM61798	Cell Culture Exposure (1MAC Halo1)	Cy3; Cy5	0.492
GSM61799	Cell Culture Exposure (1MAC Halo2)	Cy3; Cy5	0.265
GSM61800	Cell Culture Exposure (1MAC Halo3)	Cy3; Cy5	0.223
GSM61801	Cell Culture Exposure (3MAC Halo1)	Cy3; Cy5	-0.53
GSM61802	Cell Culture Exposure (3MAC Halo2)	Cy3; Cy5	-0.519
GSM61803	Cell Culture Exposure (3MAC Halo3)	Cy3; Cy5	-0.545
GSM61804	Cell Culture Exposure (3MAC ISO1)	Cy3; Cy5	0.377
GSM61805	Cell Culture Exposure (3MAC ISO2)	Cy3; Cy5	0.438
GSM61806	Cell Culture Exposure (3MAC ISO3)	Cy3; Cy5	0.408

ID	GSE48025
Title	Affymetrix Chip Data of the Transcriptome of the Rheumatoid Arthritis Rat Model Treated with Acupuncture (Affymetrix, mRNA, batch1)
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM1165929	RAT_NORA_T0_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats before therapy	8.487557297
GSM1165930	RAT_NORA_T0_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats before therapy	8.278916103
GSM1165931	RAT_RA_T0_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats before therapy	9.701841472
GSM1165932	RAT_RA_T0_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats before therapy	8.64732176
GSM1165933	RAT_NORA_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats at 1 hour after therapy	8.622588108
GSM1165934	RAT_NORA_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats at 1 hour after therapy	10.15034387
GSM1165935	RAT_AP_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour acupuncture therapy	9.036592266
GSM1165936	RAT_AP_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour acupuncture therapy	10.8938653
GSM1165937	RAT_MTX_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour MTX therapy	10.14343815
GSM1165938	RAT_MTX_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour MTX therapy	9.717214182
GSM1165939	RAT_ANE_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour ANE therapy	9.760616193
GSM1165940	RAT_ANE_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour ANE therapy	11.12614328
GSM1165941	RAT_PLA_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour placebo therapy	11.79392657
GSM1165942	RAT_PLA_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour placebo therapy	10.75444949
GSM1165943	RAT_NORA_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats at 34 days after therapy	9.523850252
GSM1165944	RAT_NORA_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats at 34 days after therapy	9.654741241
GSM1165945	RAT_AP_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days acupuncture therapy	9.581284141
GSM1165946	RAT_AP_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days acupuncture therapy	10.71406687
GSM1165947	RAT_MTX_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days MTX therapy	10.30581307
GSM1165948	RAT_MTX_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days MTX therapy	10.15632197
GSM1165949	RAT_ANE_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days ANE therapy	9.160324219
GSM1165950	RAT_ANE_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days ANE therapy	8.592044536
GSM1165951	RAT_PLA_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days placebo therapy	9.623646218
GSM1165952	RAT_PLA_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days placebo therapy	9.977061147

ID	GSE58456
Title	Affymetrix Chip Data of the Transcriptome of the Rheumatoid Arthritis Rat Model Treated with Acupuncture (Affymetrix, mRNA, batch 2)
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM1693996	Peripheral blood mononuclear cells from NORA before therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats before therapy	1672.245284
GSM1693997	Peripheral blood mononuclear cells from NORA before therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats before therapy	1221.962479
GSM1693998	Peripheral blood mononuclear cells from NORA before therapy, replicate 3	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats before therapy	515.9315236
GSM1693999	Peripheral blood mononuclear cells from RA before therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats before therapy	1776.847443
GSM1694000	Peripheral blood mononuclear cells from RA before therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats before therapy	698.6258668
GSM1694001	Peripheral blood mononuclear cells from HAP after 34 days acupuncture therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats after 34 days acupuncture therapy	1319.520749
GSM1694002	Peripheral blood mononuclear cells from HAP after 34 days acupuncture therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats after 34 days acupuncture therapy	1156.746304
GSM1694003	Peripheral blood mononuclear cells from HAP after 34 days acupuncture therapy, replicate 3	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats after 34 days acupuncture therapy	1195.154131
GSM1694004	Peripheral blood mononuclear cells from AP after 34 days acupuncture therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days acupuncture therapy	1530.353373
GSM1694005	Peripheral blood mononuclear cells from AP after 34 days acupuncture therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days acupuncture therapy	1189.748621
GSM1694006	Peripheral blood mononuclear cells from AP after 34 days acupuncture therapy, replicate 3	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days acupuncture therapy	1704.409737
GSM1694007	Peripheral blood mononuclear cells from MTXAP after 34 days MTX&acupuncture therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days methotrexate & acupuncture therapy	1989.159329
GSM1694008	Peripheral blood mononuclear cells from MTXAP after 34 days MTX&acupuncture therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days methotrexate & acupuncture therapy	3324.97182
GSM1694009	Peripheral blood mononuclear cells from MTXAP after 34 days MTX&acupuncture therapy, replicate 3	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days methotrexate & acupuncture therapy	15122.59958

ID	GSE58460
Title	Rheumatoid Arthritis Rat Model Treated with Acupuncture
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM1165929	RAT_NORA_T0_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats before therapy	8.487557297
GSM1165930	RAT_NORA_T0_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats before therapy	8.278916103
GSM1165931	RAT_RA_T0_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats before therapy	9.701841472
GSM1165932	RAT_RA_T0_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats before therapy	8.64732176
GSM1165933	RAT_NORA_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats at 1 hour after therapy	8.622588108
GSM1165934	RAT_NORA_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats at 1 hour after therapy	10.15034387
GSM1165935	RAT_AP_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour acupuncture therapy	9.036592266
GSM1165936	RAT_AP_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour acupuncture therapy	10.8938653
GSM1165937	RAT_MTX_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour MTX therapy	10.14343815
GSM1165938	RAT_MTX_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour MTX therapy	9.717214182
GSM1165939	RAT_ANE_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour ANE therapy	9.760616193
GSM1165940	RAT_ANE_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour ANE therapy	11.12614328
GSM1165941	RAT_PLA_1h_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour placebo therapy	11.79392657
GSM1165942	RAT_PLA_1h_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 1 hour placebo therapy	10.75444949
GSM1165943	RAT_NORA_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats at 34 days after therapy	9.523850252
GSM1165944	RAT_NORA_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: healthy rats at 34 days after therapy	9.654741241
GSM1165945	RAT_AP_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days acupuncture therapy	9.581284141
GSM1165946	RAT_AP_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days acupuncture therapy	10.71406687
GSM1165947	RAT_MTX_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days MTX therapy	10.30581307
GSM1165948	RAT_MTX_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days MTX therapy	10.15632197
GSM1165949	RAT_ANE_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days ANE therapy	9.160324219
GSM1165950	RAT_ANE_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days ANE therapy	8.592044536
GSM1165951	RAT_PLA_34d_1	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days placebo therapy	9.623646218
GSM1165952	RAT_PLA_34d_2	gender: Female tissue: RAT Peripheral blood mononuclear cells strain: Wistar rat subject group: RA rats after 34 days placebo therapy	9.977061147
GSM1412003	RAT_NORA_T0_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412004	RAT_NORA_T0_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412005	RAT_RA_T0_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412006	RAT_RA_T0_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412007	RAT_NORA_1h_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412008	RAT_NORA_1h_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412009	RAT_AP_1h_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412010	RAT_AP_1h_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412011	RAT_MTX_1h_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412012	RAT_MTX_1h_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412013	RAT_ANE_1h_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412014	RAT_ANE_1h_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412015	RAT_PLA_1h_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412016	RAT_PLA_1h_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412017	RAT_NORA_34d_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412018	RAT_NORA_34d_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412019	RAT_AP_34d_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412020	RAT_AP_34d_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412021	RAT_MTX_34d_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412022	RAT_MTX_34d_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412023	RAT_ANE_34d_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412024	RAT_ANE_34d_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412025	RAT_PLA_34d_1	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412026	RAT_PLA_34d_2	strain: Wistar gender: Female tissue: RAT Peripheral blood mononuclear cells
GSM1412027	RAT_RA_T0_1	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412028	RAT_RA_T0_2	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412029	RAT_AP_1h_1	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412030	RAT_AP_1h_2	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412031	RAT_PLA_1h_1	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412032	RAT_PLA_1h_2	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412033	RAT_AP_34d_1	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412034	RAT_AP_34d_2	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412035	RAT_PLA_34d_1	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1412036	RAT_PLA_34d_2	strain: Wistar gender: Female tissue: RAT Sub-epidermidis muscle tissue
GSM1693996	Peripheral blood mononuclear cells from NORA before therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats before therap	1672.245284
GSM1693997	Peripheral blood mononuclear cells from NORA before therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats before therapy	1221.962479
GSM1693998	Peripheral blood mononuclear cells from NORA before therapy, replicate 3	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats before therapy	515.9315236
GSM1693999	Peripheral blood mononuclear cells from RA before therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats before therapy	1776.847443
GSM1694000	Peripheral blood mononuclear cells from RA before therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats before therapy	698.6258668
GSM1694001	Peripheral blood mononuclear cells from HAP after 34 days acupuncture therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats after 34 days acupuncture therapy	1319.520749
GSM1694002	Peripheral blood mononuclear cells from HAP after 34 days acupuncture therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats after 34 days acupuncture therap	1156.746304
GSM1694003	Peripheral blood mononuclear cells from HAP after 34 days acupuncture therapy, replicate 3	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: healthy rats after 34 days acupuncture therapy	1195.154131
GSM1694004	Peripheral blood mononuclear cells from AP after 34 days acupuncture therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days acupuncture therapy	1530.353373
GSM1694005	Peripheral blood mononuclear cells from AP after 34 days acupuncture therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days acupuncture therapy	1189.748621
GSM1694006	Peripheral blood mononuclear cells from AP after 34 days acupuncture therapy, replicate 3	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days acupuncture therapy	1704.409737
GSM1694007	Peripheral blood mononuclear cells from MTXAP after 34 days MTX&acupuncture therapy, replicate 1	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days methotrexate & acupuncture therapy	1989.159329
GSM1694008	Peripheral blood mononuclear cells from MTXAP after 34 days MTX&acupuncture therapy, replicate 2	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days methotrexate & acupuncture therapy	3324.97182
GSM1694009	Peripheral blood mononuclear cells from MTXAP after 34 days MTX&acupuncture therapy, replicate 3	strain/background: Wistar gender: female cell type: peripheral blood mononuclear cells subject group: rheumatoid arthritis rats after 34 days methotrexate & acupuncture therapy	15122.59958

ID	GSE8911
Title	Skeletal muscle after fine needle stimulation
Organism	Rattus norvegicus

GSM	Sample info	Characteristics	Value
GSM225891	Skeletal muscle sample from fine needle-stimulated hindlimb	Strain: Lewis, Gender: Male, Body Weight: 275g, Tissue: Skeletal muscle sample from fine nnedle-stimulated hindlimb	2707.74
GSM225892	Skeletal muscle sample from control hindlimb	Strain: Lewis, Gender: Male, Body weight: 275g, Tissue: skeletal muscle sample from non fine needle-stimulated hindlimb	2146.17