HBV VIS Detail Information

> This page shows VIS [1020417] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	1020417
Chromosome	chr12
GRCh38 Location	99954391
Disease	Lymphoma, Non-Hodgkin
Sample	tumor
Target Gene	ANKS1B

Literature Information

PubMed PMID	32350851
Year	2020 Oct 15;147(8):2199-2209
Journal	International journal of cancer
Title	Characterization of hepatitis B virus infection and viral DNA integration in non-Hodgkin lymphoma.
Author	Li M,Shen Y,Chen Y,Gao H,Zhou J,Wang Q,Fan C,Zhang W,Li J,Cong H,Gu J,Gan Y,Tu H
Evidence	Hepatitis B virus (HBV) infection has been reported to be associated with non-Hodgkin lymphoma (NHL). However, the evidence is limited to the seroepidemiological study. There is a lack of evidence showing the HBV infection and integration in NHL cells. Here, we reported that in the Shanghai area, the positive rates of serum HBsAg (OR: 3.11; 95% CI: 2.20-4.41) and HBeAg (OR: 3.99; 95% CI: 1.73-9.91) were significantly higher in patients with NHL. HBsAg, HBcAg and HBV DNA were detected in 34.4%, 45.2% and 47.0% of the NHL tissues, respectively. Furthermore, by using a high-throughput viral integration detection approach (HIVID), integrated HBV DNA was identified from 50% (6/12) HBV-related NHL tissues. There were a total of 313 HBV integration sites isolated from the NHL tissues, among which four protein-coding genes (FAT2, SETX, ITGA10 and CD63) were interrupted by HBV DNA in their exons. Seven HBV preferential target genes (ANKS1B, HDAC4, EGFLAM, MAN1C1, XKR6, ZBTB38 and CCDC91) showed significantly altered expression levels in NHL, suggesting a potential role of these genes in NHL development. Taken together, HBV integration is a common phenomenon in NHL. This finding opens up a new direction of research into the mechanistic link between HBV infection and NHL.