HTLV1 VIS Detail Information

> This page shows VIS [6010326] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 6010326
VISID TVIS44030581
Chromosome chr22
GRCh38 Location 33542480
Disease   
Sample Nontumor
Virus Reference Genome KF242506
Target Gene LARGE1  
Literature Information
PubMed PMID 30307560
Year 2019 Jan 29;219(4):562-567
Journal The Journal of infectious diseases
Title Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia.
Author Turpin J,Yurick D,Khoury G,Pham H,Locarnini S,Melamed A,Witkover A,Wilson K,Purcell D,Bangham CRM,Einsiedel L
Evidence The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1-infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen. We conclude that HTLV-1/HBV coinfection may predispose to HTLV-1-associated malignant disease.
Contents
Description
  • Site Information
Detail information of site [6010326]
  • Literature Information
The details of literature that this site is associated with.