HTLV1 Target gene Detail Information

> LARGE1 Gene Search Result


Gene Information
Gene Name LARGE1
Gene ID 9215
Gene Full Name LARGE xylosyl- and glucuronyltransferase 1
Gene Alias LARGE|MDC1D|MDDGA6|MDDGB6
Transcripts ENSG00000133424
Virus HTLV1
Gene Type protein-coding
HPA Location Info
Membrane Info Disease related genes, Human disease related genes, Predicted intracellular proteins
Uniport_ID O95461
HGNC ID HGNC:6511
OMIM ID 603590
Summary This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018]
Target gene [LARGE1] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6006390 chr22 4 38 27 69 View
6010326 chr22 3 13 16 32 View
6013296 chr22 18 0 1 19 View
6014283 chr22 7 1 9 17 View
6015540 chr22 14 0 0 14 View
6018324 chr22 7 2 0 9 View
6022683 chr22 2 3 0 5 View
6023419 chr22 4 0 0 4 View
6025364 chr22 3 0 0 3 View

Target gene [LARGE1] related to Omics data
Data ID Experiment type Sample number Platform
GSE52244 Expression array 15 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE10789 Expression array 6 NCI/ATC Hs-OperonV3
GSE224047 RNA-seq 10 Illumina NextSeq 500 (Homo sapiens)
C
  GSE94732 		Chip-seq 24 Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE94732 - LARGE1 peak across samples

Peak Plot