XMRV VIS Detail Information

> This page shows VIS [8000061] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	8000061
Chromosome	chr17
GRCh38 Location	48048344, 48060771
Disease	Squamous Cell Carcinoma of Head and Neck
Sample	BHY
Target Gene	COPZ2 CBX1

Literature Information

PubMed PMID	25485619
Year	2015 Mar;33(3):306-12
Journal	Nature biotechnology
Title	A comprehensive transcriptional portrait of human cancer cell lines.
Author	Klijn C,Durinck S,Stawiski EW,Haverty PM,Jiang Z,Liu H,Degenhardt J,Mayba O,Gnad F,Liu J,Pau G,Reeder J,Cao Y,Mukhyala K,Selvaraj SK,Yu M,Zynda GJ,Brauer MJ,Wu TD,Gentleman RC,Manning G,Yauch RL,Bourgon R,Stokoe D,Modrusan Z,Neve RM,de Sauvage FJ,Settleman J,Seshagiri S,Zhang Z
Evidence	Tumor-derived cell lines have served as vital models to advance our understanding of oncogene function and therapeutic responses. Although substantial effort has been made to define the genomic constitution of cancer cell line panels, the transcriptome remains understudied. Here we describe RNA sequencing and single-nucleotide polymorphism (SNP) array analysis of 675 human cancer cell lines. We report comprehensive analyses of transcriptome features including gene expression, mutations, gene fusions and expression of non-human sequences. Of the 2,200 gene fusions catalogued, 1,435 consist of genes not previously found in fusions, providing many leads for further investigation. We combine multiple genome and transcriptome features in a pathway-based approach to enhance prediction of response to targeted therapeutics. Our results provide a valuable resource for studies that use cancer cell lines.