Gene Information
|
Gene Name
|
AFDN |
|
Gene ID
|
4301
|
|
Gene Full Name
|
afadin, adherens junction formation factor |
|
Gene Alias
|
AF6|MLL-AF6|MLLT4|l-afadin |
|
Transcripts
|
ENSG00000130396
|
|
Virus
|
HTLV1 |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane, Cell Junctions;Nucleoplasm; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
|
Uniport_ID
|
P55196
|
|
HGNC ID
|
HGNC:7137
|
|
OMIM ID
|
159559 |
|
Summary
|
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011] |
Target gene [AFDN] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 6002592 |
chr6 |
128 |
48 |
48 |
224 |
View |
Target gene [AFDN] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE52244
|
Expression array |
15 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
GSE10789
|
Expression array |
6 |
NCI/ATC Hs-OperonV3 |
|
GSE224047
|
RNA-seq |
10 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE94732
|
Chip-seq |
24 |
Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE94732 - AFDN peak across samples
|
Peak Plot
|
|
|
HTLV1 Target gene Detail Information
