Gene Name	AFG1L
Gene ID	246269
Gene Full Name	AFG1 like ATPase
Gene Alias	AFG1|LACE1|c222389
Transcripts	ENSG00000135537
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Intracellular and membrane;
Membrane Info	Predicted intracellular proteins
Uniport_ID	Q8WV93
HGNC ID	HGNC:16411
OMIM ID	617469
Summary	This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6025160	chr6	3	0	0	3	View

Data ID	Experiment type	Sample number	Platform
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - AFG1L peak across samples

Peak Plot