Gene Information
|
Gene Name
|
BMAL1 |
|
Gene ID
|
406
|
|
Gene Full Name
|
basic helix-loop-helix ARNT like 1 |
|
Gene Alias
|
ARNTL|ARNTL1|BMAL1c|JAP3|MOP3|PASD3|TIC|bHLHe5 |
|
Transcripts
|
ENSG00000133794
|
|
Virus
|
HPV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Vesicles; 
|
|
Membrane Info
|
Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
O00327
|
|
HGNC ID
|
HGNC:701
|
|
OMIM ID
|
602550 |
|
Summary
|
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021] |
Target gene [BMAL1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
Target gene [BMAL1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE183048
|
Chip-seq |
24 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE140662
|
Expression array |
8 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
C GSE143026
|
ATAC-seq;Chip-seq;RNA-seq |
30 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE181805
|
Expression array |
25 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE183048 - BMAL1 peak across samples
|
Peak Plot
|
> Dataset: GSE143026 - BMAL1 peak across samples
|
Peak Plot
|
|
|
HPV Target gene Detail Information
