Virus Dataset Detail

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Dataset Information
Accession GSE181805
Status 2021/12/1
Title Comparison between HPV+ / p16+ versus the HPV-/p16- from HNSCC patients
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Head and neck squamous cell carcinomas are heterogeneous neoplasms that show clinical and biological differences in association with the human papillomavirus (HPV). To provide adequate therapeutic strategies, biological and clinical characterization is essential to stratify patients based on prognostic and predictive factors. Reports on HNSCC are scarce in Mexico, thus in the present study, we analyze 414 cases of HNSCC, including those of the oropharynx (OPSCC), larynx (LASCC), and oral cavity (OCSCC). We determined the presence of HPV and p16 expression. Global expression profiles were analyzed with Affymetrix HTA 2.0 microarray in 25 selected cases HPV+/p16+ versus HPV-/p16-. In our study we analyze 25 samples derived from HNSCC patients. 18 samples were HPV-/p16- and 7 HPV+/p16+. We compared the HPV-/p16- versus the HPV+/p16+ and identified differentially expressed RNAs with a fold change greater than 1.5 or less than -1.5. These data were used to obtain 98 genes that are differentially expressed in absence of HPV. The present study offers information regarding clinical and molecular characteristics of HNSCC, both associated and unassociated with HPV, in Mexican patients.
Samples
GSM ID Sample info Characteristics Description
GSM5511627 HN070 HNSCC (Oral cavity) age:55; gender:woman; disease status:Negative HNSCC (Oral cavity)
GSM5511628 HN087 HNSCC (Oral cavity) age:49; gender:men; disease status:HPV16 HNSCC (Oral cavity)
GSM5511629 HN182 HNSCC (Larynx) age:na; gender:men; disease status:Negative HNSCC (Larynx)
GSM5511630 HN183 HNSCC (Oral cavity) age:66; gender:men; disease status:Negative HNSCC (Oral cavity)
GSM5511631 HN184 HNSCC (Pharynx) age:63; gender:men; disease status:HPV16 HNSCC (Pharynx)
GSM5511632 HN185 HNSCC (Larynx) age:na; gender:men; disease status:Negative HNSCC (Larynx)
GSM5511633 HN186 HNSCC (Larynx) age:36; gender:woman; disease status:HPV16 HNSCC (Larynx)
GSM5511634 HN187 HNSCC (Pharynx) age:49; gender:men; disease status:HPV16 HNSCC (Pharynx)
GSM5511635 HN188 HNSCC (Oral cavity) age:80; gender:woman; disease status:Negative HNSCC (Oral cavity)
GSM5511636 HN189 HNSCC (Larynx) age:50; gender:men; disease status:Negative HNSCC (Larynx)
GSM5511637 HN193 HNSCC (Larynx) age:68; gender:men; disease status:Negative HNSCC (Larynx)
GSM5511638 HN194 HNSCC (Larynx) age:59; gender:men; disease status:Negative HNSCC (Larynx)
GSM5511639 HN195 HNSCC (Oral cavity) age:na; gender:men; disease status:Negative HNSCC (Oral cavity)
GSM5511640 HN199 HNSCC (Larynx) age:78; gender:men; disease status:Negative HNSCC (Larynx)
GSM5511641 HN200 HNSCC (Larynx) age:80; gender:men; disease status:Negative HNSCC (Larynx)
GSM5511642 HN201 HNSCC (Pharynx) age:64; gender:woman; disease status:HPV16 HNSCC (Pharynx)
GSM5511643 HN202 HNSCC (Pharynx) age:84; gender:men; disease status:Negative HNSCC (Pharynx)
GSM5511644 HN203 HNSCC (Oral cavity) age:67; gender:woman; disease status:HPV16 HNSCC (Oral cavity)
GSM5511645 HN206 HNSCC (Oral cavity) age:36; gender:woman; disease status:Negative HNSCC (Oral cavity)
GSM5511646 HN207 HNSCC (Larynx) age:83; gender:woman; disease status:Negative HNSCC (Larynx)
GSM5511647 HN209 HNSCC (Larynx) age:52; gender:men; disease status:HPV39 HNSCC (Larynx)
GSM5511648 HN210 HNSCC (Larynx) age:61; gender:men; disease status:Negative HNSCC (Larynx)
GSM5511649 HN211 HNSCC (Oral cavity) age:73; gender:woman; disease status:Negative HNSCC (Oral cavity)
GSM5511650 HN213 HNSCC (Oral cavity) age:na; gender:woman; disease status:Negative HNSCC (Oral cavity)
GSM5511651 HN215 HNSCC (Oral cavity) age:48; gender:men; disease status:Negative HNSCC (Oral cavity)
Platform GPL17586  : [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Literature 34830760  
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* p<0.05 ** p<0.01