Gene Information
|
Gene Name
|
CCL5 |
|
Gene ID
|
6352
|
|
Gene Full Name
|
C-C motif chemokine ligand 5 |
|
Gene Alias
|
D17S136E|RANTES|SCYA5|SIS-delta|SISd|TCP228|eoCP |
|
Transcripts
|
ENSG00000271503
|
|
Virus
|
EBOV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Secreted to blood; 
|
|
Membrane Info
|
Cancer-related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
|
Uniport_ID
|
P13501
|
|
HGNC ID
|
HGNC:10632
|
|
OMIM ID
|
187011 |
|
Summary
|
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
Target gene [CCL5] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
| ID |
PMID |
Mutation |
Gene/Protein/Region |
Encoding Gene/Protein |
Disease |
Description |
Detail |
| 1 |
18353943 |
R312A |
VP35
|
VP35
|
Cell line
|
G
I
T
|
View |
Target gene [CCL5] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
E GSE96590
|
RNA-seq |
20 |
Illumina HiSeq 1000 (Homo sapiens) |
|
GSE80131
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: GSE96590 - CCL5 expression across samples
|
Volcano Plot
|
Bar Plot
|
|
|
EBOV Target gene Detail Information
