Gene Information
|
Gene Name
|
CD209 |
|
Gene ID
|
30835
|
|
Gene Full Name
|
CD209 molecule |
|
Gene Alias
|
CDSIGN|CLEC4L|DC-SIGN|DC-SIGN1|hDC-SIGN |
|
Transcripts
|
ENSG00000090659
|
|
Virus
|
DENV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Intracellular and membrane; 
|
|
Membrane Info
|
CD markers, Predicted intracellular proteins, Predicted membrane proteins |
|
Uniport_ID
|
Q9NNX6
|
|
HGNC ID
|
HGNC:1641
|
|
OMIM ID
|
604672 |
|
Summary
|
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020] |
Target gene [CD209] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [CD209] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE132367
|
RNA-seq |
57 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE152255
|
RNA-seq |
99 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE279208
|
RNA-seq |
26 |
DNBSEQ-G400 (Homo sapiens) |
|
GSE155672
|
RNA-seq |
12 |
HiSeq X Ten (Homo sapiens) |
|
|
DENV Target gene Detail Information
