Gene Name	CEMIP2
Gene ID	23670
Gene Full Name	cell migration inducing hyaluronidase 2
Gene Alias	TMEM2
Transcripts	ENSG00000135048
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Vesicles, Cytosol;
Membrane Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9UHN6
HGNC ID	HGNC:11869
OMIM ID	605835
Summary	This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010281	chr9	28	4	0	32	View
6027548	chr9	2	0	0	2	View
6028187	chr9	0	1	0	1	View

Data ID	Experiment type	Sample number	Platform
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE224047	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens)
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - CEMIP2 peak across samples

Peak Plot