Gene Name	CGAS
Gene ID	115004
Gene Full Name	cyclic GMP-AMP synthase
Gene Alias	C6orf150|D4|MB21D1|h-cGAS
Transcripts	ENSG00000164430
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Nuclear bodies, Cytosol;
Membrane Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q8N884
HGNC ID	HGNC:21367
OMIM ID	613973
Summary	Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; molecular condensate scaffold activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including defense response to symbiont; intracellular signal transduction; and regulation of defense response. Located in nuclear body; plasma membrane; and site of double-strand break. Is active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6022310	chr6	5	0	0	5	View

Data ID	Experiment type	Sample number	Platform
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
GSE224047	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens)
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - CGAS peak across samples

Peak Plot