Gene Name	CTSL
Gene ID	1514
Gene Full Name	cathepsin L
Gene Alias	CATL|CTSL1|MEP
Transcripts	ENSG00000135047
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Golgi apparatus, Vesicles;Intracellular and membrane;
Membrane Info	Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P07711
HGNC ID	HGNC:2537
OMIM ID	116880
Summary	The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	33593971	A82V	GP	GP	Cell line	D G R T	View

Data ID	Experiment type	Sample number	Platform
E   GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE96590 - CTSL expression across samples

Volcano Plot

Bar Plot