Gene Name	CXCL1
Gene ID	2919
Gene Full Name	C-X-C motif chemokine ligand 1
Gene Alias	FSP|GRO1|GROa|MGSA|MGSA-a|NAP-3|SCYB1
Transcripts	ENSG00000163739
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Secreted to blood;
Membrane Info	Cancer-related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P09341
HGNC ID	HGNC:4602
OMIM ID	155730
Summary	This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	31717793	S246P	GP	GP	Cell line	I T	View
2	31717793	S65P	GP	GP	Cell line	I T	View
3	31717793	F934L	L	L	Cell line	I T	View
4	31717793	I1532V	L	L	Cell line	I T	View
5	31717793	C2357A	NP	NP	Cell line	I T	View
6	31717793	H630N	NP	NP	Cell line	I T	View
7	31717793	S72G	NP	NP	Cell line	I T	View
8	31717793	A10979T	VP24	VP24	Cell line	I T	View
9	31717793	K212M	VP24	VP24	Cell line	I T	View
10	31717793	T50I	VP24	VP24	Cell line	I T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)