Gene Name	DESI2
Gene ID	51029
Gene Full Name	desumoylating isopeptidase 2
Gene Alias	C1orf121|CGI-146|DESI|DESI1|DeSI-2|FAM152A|PNAS-4|PPPDE1
Transcripts	ENSG00000121644
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Vesicles;
Membrane Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q9BSY9
HGNC ID	HGNC:24264
OMIM ID	614638
Summary	Enables deubiquitinase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in macromolecule depalmitoylation and proteolysis. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1005213	chr1	43	13	2	58	View

Data ID	Experiment type	Sample number	Platform
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
E   GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE94660 - DESI2 expression across samples

Volcano Plot

Bar Plot