Gene Information
|
Gene Name
|
EIF2AK2 |
|
Gene ID
|
5610
|
|
Gene Full Name
|
eukaryotic translation initiation factor 2 alpha kinase 2 |
|
Gene Alias
|
DYT33|EIF2AK1|LEUDEN|PKR|PPP1R83|PRKR |
|
Transcripts
|
ENSG00000055332
|
|
Virus
|
JEV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Cytosol; 
|
|
Membrane Info
|
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
|
Uniport_ID
|
P19525
|
|
HGNC ID
|
HGNC:9437
|
|
OMIM ID
|
176871 |
|
Summary
|
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021] |
Target gene [EIF2AK2] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [EIF2AK2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE221680
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
|
JEV Target gene Detail Information
