Gene Name	EIF2S1
Gene ID	1965
Gene Full Name	eukaryotic translation initiation factor 2 subunit alpha
Gene Alias	EIF-2|EIF-2A|EIF-2alpha|EIF2|EIF2A
Transcripts	ENSG00000134001
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Cytosol;
Membrane Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	P05198
HGNC ID	HGNC:3265
OMIM ID	603907
Summary	The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	40288648	E619K	NP	NP	Cell line	D R S T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)