Gene Name	GET1
Gene ID	7485
Gene Full Name	guided entry of tail-anchored proteins factor 1
Gene Alias	CHD5|WRB
Transcripts	ENSG00000182093
Virus	HPV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	O00258
HGNC ID	HGNC:12790
OMIM ID	602915
Summary	This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5015712	chr21	16	37	5	58	View

Data ID	Experiment type	Sample number	Platform
C   GSE183048	Chip-seq	24	Illumina HiSeq 4000 (Homo sapiens)
GSE181805	Expression array	25	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE140662	Expression array	8	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
TCGA_CESC	DNA methylation sequencing;RNA-seq	288	TCGA
C   GSE143026	ATAC-seq;Chip-seq;RNA-seq	30	Illumina HiSeq 2500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE183048 - GET1 peak across samples

Peak Plot

> Dataset: GSE143026 - GET1 peak across samples

Peak Plot