Gene Name	GSAP
Gene ID	54103
Gene Full Name	gamma-secretase activating protein
Gene Alias	PION
Transcripts	ENSG00000186088
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Vesicles;
Membrane Info	Predicted intracellular proteins
Uniport_ID	A4D1B5
HGNC ID	HGNC:28042
OMIM ID	613552
Summary	Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6011358	chr7	20	0	7	27	View
6014294	chr7	17	0	0	17	View
6016819	chr7	1	4	6	11	View

Data ID	Experiment type	Sample number	Platform
GSE10789	Expression array	6	NCI/ATC Hs-OperonV3
GSE224047	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens)
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - GSAP peak across samples

Peak Plot