Accession	GSE189602
Status	2023/5/3
Title	DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Illumina]
Organism	Homo sapiens
Experiment type	Methylation profiling by array
Summary	Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T-cells caused by human T-cell lymphotropic virus type 1 (HTLV-1). Recently, it has been noted that some epigenome abnormalities including DNA methylation and tri-methylation at histone H3Lys27 (H3K27me3) contribute to malignant transformation of ATL. Hence, we investigate the combined effect of DNA demethylating agents and enhancer of zeste homolog 2 (EZH2), which catalyze H3K27me3, inhibitors in ATL. Methylaome analyse revealed that OR21 and the combination changes DNA methylation.
Samples	GSM ID Sample info Characteristics Description GSM5704335 MT-1 control treatment:control; cell line:MT-1 R05C01 GSM5704336 MT-1 OR21 treatment:500nM OR21 treated; cell line:MT-1 R06C01 GSM5704337 MT-1 EPZ treatment:2500nM EPZ treated; cell line:MT-1 R07C01 GSM5704338 MT-1 Comb treatment:500nM OR21 and 2500nM EPZ treated; cell line:MT-1 R08C01
Platform	GPL21145  : Infinium MethylationEPIC
Literature	36516085
Download	Download Methylation Analysis Data