Gene Information
|
Gene Name
|
HNF4A |
|
Gene ID
|
3172
|
|
Gene Full Name
|
hepatocyte nuclear factor 4 alpha |
|
Gene Alias
|
FRTS4|HNF4|HNF4a7|HNF4a8|HNF4a9|HNF4alpha|MODY|MODY1|NR2A1|NR2A21|TCF|TCF-14|TCF14 |
|
Transcripts
|
ENSG00000101076
|
|
Virus
|
HBV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm; 
|
|
Membrane Info
|
Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
P41235
|
|
HGNC ID
|
HGNC:5024
|
|
OMIM ID
|
600281 |
|
Summary
|
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012] |
Target gene [HNF4A] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 1007806 |
chr20 |
7 |
15 |
2 |
24 |
View |
| 1011395 |
chr20 |
6 |
3 |
0 |
9 |
View |
| 1011457 |
chr20 |
3 |
4 |
2 |
9 |
View |
| 1012254 |
chr20 |
7 |
0 |
0 |
7 |
View |
| 1012757 |
chr20 |
6 |
0 |
0 |
6 |
View |
Target gene [HNF4A] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE236281
|
RNA-seq |
12 |
Illumina MiSeq (Homo sapiens) |
|
C GSE35465
|
Chip-seq;RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
GSE199850
|
scRNA-seq |
1 |
HiSeq X Ten (Homo sapiens) |
|
C GSE68402
|
Chip-seq |
26 |
Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
|
TCGA_LIHC_HBV
|
DNA methylation sequencing;RNA-seq |
97 |
TCGA |
|
C GSE270130
|
Chip-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE224901
|
RNA-seq |
21 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE100400
|
Chip-seq;RNA-seq;4C_cccDNA |
31 |
Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus) |
|
GSE173897
|
RNA-seq |
95 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE262515
|
RNA-seq |
21 |
Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus) |
|
GSE110345
|
RNA-seq |
4 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE131257
|
ATAC-seq;RNA-seq |
19 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE94660
|
RNA-seq |
42 |
Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE35465 - HNF4A peak across samples
|
Peak Plot
|
> Dataset: GSE68402 - HNF4A peak across samples
|
Peak Plot
|
> Dataset: GSE270130 - HNF4A peak across samples
|
Peak Plot
|
> Dataset: GSE131257 - HNF4A peak across samples
|
Peak Plot
|
|
|
HBV Target gene Detail Information
