Gene Name	IFIH1
Gene ID	64135
Gene Full Name	interferon induced with helicase C domain 1
Gene Alias	AGS7|Hlcd|IDDM19|IMD95|MDA-5|MDA5|RLR-2|SGMRT1
Transcripts	ENSG00000115267
Virus	EBOV
Gene Type	protein-coding
HPA Location Info
Membrane Info	Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q9BYX4
HGNC ID	HGNC:18873
OMIM ID	606951
Summary	IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	18353943	R312A	VP35	VP35	Cell line	G I T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)