Gene Information
|
Gene Name
|
IL15 |
|
Gene ID
|
3600
|
|
Gene Full Name
|
interleukin 15 |
|
Gene Alias
|
IL-15 |
|
Transcripts
|
ENSG00000164136
|
|
Virus
|
EBOV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm, Nuclear speckles;Secreted to blood; 
|
|
Membrane Info
|
Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins |
|
Uniport_ID
|
P40933
|
|
HGNC ID
|
HGNC:5977
|
|
OMIM ID
|
600554 |
|
Summary
|
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011] |
Target gene [IL15] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [IL15] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE96590
|
RNA-seq |
20 |
Illumina HiSeq 1000 (Homo sapiens) |
|
GSE80131
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
|
EBOV Target gene Detail Information
