Gene Name	IL1B
Gene ID	3553
Gene Full Name	interleukin 1 beta
Gene Alias	IL-1|IL1-BETA|IL1F2|IL1beta
Transcripts	ENSG00000125538
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Secreted to blood;
Membrane Info	Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Uniport_ID	P01584
HGNC ID	HGNC:5992
OMIM ID	147720
Summary	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	31717793	S246P	GP	GP	Cell line	I T	View
2	31717793	S65P	GP	GP	Cell line	I T	View
3	31717793	F934L	L	L	Cell line	I T	View
4	31717793	I1532V	L	L	Cell line	I T	View
5	31717793	C2357A	NP	NP	Cell line	I T	View
6	31717793	H630N	NP	NP	Cell line	I T	View
7	31717793	S72G	NP	NP	Cell line	I T	View
8	31717793	A10979T	VP24	VP24	Cell line	I T	View
9	31717793	K212M	VP24	VP24	Cell line	I T	View
10	31717793	T50I	VP24	VP24	Cell line	I T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)