Gene Name	IL22
Gene ID	50616
Gene Full Name	interleukin 22
Gene Alias	IL-21|IL-22|IL-D110|IL-TIF|ILTIF|TIFIL-23|TIFa|zcyto18
Transcripts	ENSG00000127318
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Secreted to blood;
Membrane Info	Predicted secreted proteins
Uniport_ID	Q9GZX6
HGNC ID	HGNC:14900
OMIM ID	605330
Summary	This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Dec 2021]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	31717793	S246P	GP	GP	Cell line	I T	View
2	31717793	S65P	GP	GP	Cell line	I T	View
3	31717793	F934L	L	L	Cell line	I T	View
4	31717793	I1532V	L	L	Cell line	I T	View
5	31717793	C2357A	NP	NP	Cell line	I T	View
6	31717793	H630N	NP	NP	Cell line	I T	View
7	31717793	S72G	NP	NP	Cell line	I T	View
8	31717793	A10979T	VP24	VP24	Cell line	I T	View
9	31717793	K212M	VP24	VP24	Cell line	I T	View
10	31717793	T50I	VP24	VP24	Cell line	I T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)