Gene Information
|
Gene Name
|
IL6 |
|
Gene ID
|
3569
|
|
Gene Full Name
|
interleukin 6 |
|
Gene Alias
|
BSF-2|BSF2|CDF|HGF|HSF|IFN-beta-2|IFNB2|IL-6 |
|
Transcripts
|
ENSG00000136244
|
|
Virus
|
EBOV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Vesicles;Secreted to blood; 
|
|
Membrane Info
|
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
|
Uniport_ID
|
P05231
|
|
HGNC ID
|
HGNC:6018
|
|
OMIM ID
|
147620 |
|
Summary
|
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020] |
Target gene [IL6] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
Target gene [IL6] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE96590
|
RNA-seq |
20 |
Illumina HiSeq 1000 (Homo sapiens) |
|
GSE80131
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
|
|
EBOV Target gene Detail Information
