Gene Information
|
Gene Name
|
ISG15 |
|
Gene ID
|
9636
|
|
Gene Full Name
|
ISG15 ubiquitin like modifier |
|
Gene Alias
|
G1P2|IFI15|IMD38|IP17|UCRP|hUCRP |
|
Transcripts
|
ENSG00000187608
|
|
Virus
|
EBOV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Secreted to blood; 
|
|
Membrane Info
|
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
|
Uniport_ID
|
P05161
|
|
HGNC ID
|
HGNC:4053
|
|
OMIM ID
|
147571 |
|
Summary
|
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] |
Target gene [ISG15] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
| ID |
PMID |
Mutation |
Gene/Protein/Region |
Encoding Gene/Protein |
Disease |
Description |
Detail |
| 1 |
18353943 |
R312A |
VP35
|
VP35
|
Cell line
|
G
I
T
|
View |
Target gene [ISG15] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
E GSE96590
|
RNA-seq |
20 |
Illumina HiSeq 1000 (Homo sapiens) |
|
GSE80131
|
RNA-seq |
6 |
Illumina HiSeq 2500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: GSE96590 - ISG15 expression across samples
|
Volcano Plot
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Bar Plot
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|
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EBOV Target gene Detail Information
