Gene Name	KPNA5
Gene ID	3841
Gene Full Name	karyopherin subunit alpha 5
Gene Alias	IPOA6|SRP6
Transcripts	ENSG00000196911
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Cytosol;
Membrane Info	Predicted intracellular proteins, Transporters
Uniport_ID	O15131
HGNC ID	HGNC:6398
OMIM ID	604545
Summary	The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	37243162	N135A	VP24	VP24	Cell line	T	View
2	37243162	N135Q	VP24	VP24	Cell line	T	View
3	37243162	P83A	VP24	VP24	Cell line	T	View
4	37243162	P83S	VP24	VP24	Cell line	T	View
5	37243162	R140A	VP24	VP24	Cell line	T	View
6	37243162	R140H	VP24	VP24	Cell line	T	View
7	37243162	V141A	VP24	VP24	Cell line	T	View
8	37243162	V141G	VP24	VP24	Cell line	T	View
9	27009368	M136L	VP24	VP24		G T	View
10	27009368	Q139R	VP24	VP24		G T	View
11	27009368	S26T	VP35	VP35		G T	View
12	28812539	F134A	VP24	VP24		T	View
13	28812539	M136A	VP24	VP24		T	View
14	28812539	R137A	VP24	VP24		T	View
15	28812539	T138A	VP24	VP24		T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)