Gene Name	KPNA6
Gene ID	23633
Gene Full Name	karyopherin subunit alpha 6
Gene Alias	IPOA7
Transcripts	ENSG00000025800
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Cytosol;Nucleoplasm;
Membrane Info	Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	O60684
HGNC ID	HGNC:6399
OMIM ID	610563
Summary	Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	37243162	N135A	VP24	VP24	Cell line	T	View
2	37243162	N135Q	VP24	VP24	Cell line	T	View
3	37243162	P83A	VP24	VP24	Cell line	T	View
4	37243162	P83S	VP24	VP24	Cell line	T	View
5	37243162	R140A	VP24	VP24	Cell line	T	View
6	37243162	R140H	VP24	VP24	Cell line	T	View
7	37243162	V141A	VP24	VP24	Cell line	T	View
8	37243162	V141G	VP24	VP24	Cell line	T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)