Gene Name	LINC00673
Gene ID	100499467
Gene Full Name	long intergenic non-protein coding RNA 673
Gene Alias	ERRLR01|HI-LNC75|HILNC75|LUCAIR1|RASON|SLNCR|SLNCR1
Transcripts	ENSG00000227036
Virus	HTLV1
Gene Type	ncRNA
HGNC ID	HGNC:44354
OMIM ID	617079
Summary	This gene produces a long non-protein coding RNA that is involved in the regulation of gene expression during tumor progression. This transcript can promote cell proliferation in gastric cancer through interaction with enhancer of zeste 2 and other epigenetic suppressors of gene expression, thereby downregulating target genes including Kruppel like factors 2 and 4. This transcript may also act as a tumor suppressor by promoting interaction between protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) and ubiquitin ligase, resulting in degradation of Ptpn11 and lowered oncogenic signalling. Naturally-occurring variation at this locus results in the formation of a binding site for miR-1231, which negatively regulates activity of this transcript. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002760	chr17	65	87	59	211	View
6004937	chr17	100	0	0	100	View
6005312	chr17	88	0	2	90	View
6012253	chr17	21	2	0	23	View

Data ID	Experiment type	Sample number	Platform
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - LINC00673 peak across samples

Peak Plot