Gene Name	MALRD1
Gene ID	340895
Gene Full Name	MAM and LDL receptor class A domain containing 1
Gene Alias	C10orf112|DIET1|bA265G8.2
Transcripts	ENSG00000204740
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Golgi apparatus;
Membrane Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q5VYJ5
HGNC ID	HGNC:24331
OMIM ID	617715
Summary	This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006221	chr10	42	9	21	72	View
6008750	chr10	41	1	0	42	View
6009090	chr10	4	35	0	39	View
6013245	chr10	19	1	0	20	View
6026708	chr10	0	0	2	2	View
6028794	chr10	0	1	0	1	View
6031244	chr10	0	0	0	0	View
6032956	chr10	0	0	0	0	View

Data ID	Experiment type	Sample number	Platform
GSE189602	Methylation profiling (Array)	4	Infinium MethylationEPIC
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - MALRD1 peak across samples

Peak Plot