Gene Information
|
Gene Name
|
NRXN1 |
|
Gene ID
|
9378
|
|
Gene Full Name
|
neurexin 1 |
|
Gene Alias
|
Hs.22998|PTHSL2|SCZD17 |
|
Transcripts
|
ENSG00000179915
|
|
Virus
|
HBV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Plasma membrane;Intracellular and membrane; 
|
|
Membrane Info
|
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
|
Uniport_ID
|
P58400, Q9ULB1
|
|
HGNC ID
|
HGNC:8008
|
|
OMIM ID
|
600565 |
|
Summary
|
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016] |
Target gene [NRXN1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 1014270 |
chr2 |
0 |
4 |
0 |
4 |
View |
| 1014427 |
chr2 |
0 |
3 |
0 |
3 |
View |
| 1014428 |
chr2 |
0 |
3 |
0 |
3 |
View |
| 1016057 |
chr2 |
0 |
1 |
1 |
2 |
View |
| 1016473 |
chr2 |
0 |
1 |
0 |
1 |
View |
| 1019597 |
chr2 |
0 |
0 |
0 |
0 |
View |
| 1020071 |
chr2 |
1 |
1 |
0 |
2 |
View |
| 1022681 |
chr2 |
0 |
3 |
0 |
3 |
View |
| 1022682 |
chr2 |
0 |
3 |
0 |
3 |
View |
| 1041269 |
chr2 |
0 |
0 |
3 |
3 |
View |
Target gene [NRXN1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE236281
|
RNA-seq |
12 |
Illumina MiSeq (Homo sapiens) |
|
C GSE35465
|
Chip-seq;RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE68402
|
Chip-seq |
26 |
Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
|
TCGA_LIHC_HBV
|
DNA methylation sequencing;RNA-seq |
97 |
TCGA |
|
C GSE270130
|
Chip-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE224901
|
RNA-seq |
21 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE100400
|
Chip-seq;RNA-seq;4C_cccDNA |
31 |
Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus) |
|
GSE173897
|
RNA-seq |
95 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE262515
|
RNA-seq |
21 |
Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus) |
|
GSE110345
|
RNA-seq |
4 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE131257
|
ATAC-seq;RNA-seq |
19 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE94660
|
RNA-seq |
42 |
Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE35465 - NRXN1 peak across samples
|
Peak Plot
|
> Dataset: GSE68402 - NRXN1 peak across samples
|
Peak Plot
|
> Dataset: GSE270130 - NRXN1 peak across samples
|
Peak Plot
|
> Dataset: GSE131257 - NRXN1 peak across samples
|
Peak Plot
|
|
|
HBV Target gene Detail Information
