Gene Information
|
Gene Name
|
PAK5 |
|
Gene ID
|
57144
|
|
Gene Full Name
|
p21 (RAC1) activated kinase 5 |
|
Gene Alias
|
PAK7 |
|
Transcripts
|
ENSG00000101349
|
|
Virus
|
HBV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Nuclear membrane, Mitochondria, Cytosol; 
|
|
Membrane Info
|
Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
|
Uniport_ID
|
Q9P286
|
|
HGNC ID
|
HGNC:15916
|
|
OMIM ID
|
608038 |
|
Summary
|
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
Target gene [PAK5] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 1008062 |
chr20 |
22 |
0 |
0 |
22 |
View |
| 1022788 |
chr20 |
22 |
0 |
0 |
22 |
View |
Target gene [PAK5] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE236281
|
RNA-seq |
12 |
Illumina MiSeq (Homo sapiens) |
|
C GSE35465
|
Chip-seq;RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE68402
|
Chip-seq |
26 |
Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
|
TCGA_LIHC_HBV
|
DNA methylation sequencing;RNA-seq |
97 |
TCGA |
|
C GSE270130
|
Chip-seq |
27 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE224901
|
RNA-seq |
21 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE100400
|
Chip-seq;RNA-seq;4C_cccDNA |
31 |
Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus) |
|
GSE173897
|
RNA-seq |
95 |
Illumina HiSeq 4000 (Homo sapiens) |
|
C GSE131257
|
ATAC-seq;RNA-seq |
19 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE94660
|
RNA-seq |
42 |
Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE35465 - PAK5 peak across samples
|
Peak Plot
|
> Dataset: GSE68402 - PAK5 peak across samples
|
Peak Plot
|
> Dataset: GSE270130 - PAK5 peak across samples
|
Peak Plot
|
> Dataset: GSE131257 - PAK5 peak across samples
|
Peak Plot
|
|
|
HBV Target gene Detail Information
