Gene Information
|
Gene Name
|
PRKN |
|
Gene ID
|
5071
|
|
Gene Full Name
|
parkin RBR E3 ubiquitin protein ligase |
|
Gene Alias
|
AR-JP|LPRS2|PARK2|PDJ |
|
Transcripts
|
ENSG00000185345
|
|
Virus
|
HPV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nuclear speckles;Cytosol; 
|
|
Membrane Info
|
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
|
Uniport_ID
|
O60260
|
|
HGNC ID
|
HGNC:8607
|
|
OMIM ID
|
602544 |
|
Summary
|
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008] |
Target gene [PRKN] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 5002661 |
chr6 |
5 |
4 |
0 |
9 |
View |
| 5002710 |
chr6 |
8 |
0 |
0 |
8 |
View |
| 5003291 |
chr6 |
4 |
0 |
0 |
4 |
View |
| 5004646 |
chr6 |
0 |
0 |
0 |
0 |
View |
| 5013676 |
chr6 |
92 |
11 |
48 |
151 |
View |
| 5013677 |
chr6 |
3 |
2 |
0 |
5 |
View |
| 5013678 |
chr6 |
49 |
15 |
1 |
65 |
View |
| 5013679 |
chr6 |
115 |
32 |
3 |
150 |
View |
| 5016182 |
chr6 |
0 |
1 |
1 |
2 |
View |
| 5016183 |
chr6 |
6 |
0 |
0 |
6 |
View |
Target gene [PRKN] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
C GSE183048
|
Chip-seq |
24 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE181805
|
Expression array |
25 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
GSE140662
|
Expression array |
8 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
E TCGA_CESC
|
DNA methylation sequencing;RNA-seq |
288 |
TCGA |
|
C GSE143026
|
ATAC-seq;Chip-seq;RNA-seq |
30 |
Illumina HiSeq 2500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.
> Dataset: TCGA_CESC - PRKN expression across samples
|
Volcano Plot
|
Bar Plot
|
|
|
HPV Target gene Detail Information
