Gene Name	PRKN
Gene ID	5071
Gene Full Name	parkin RBR E3 ubiquitin protein ligase
Gene Alias	AR-JP|LPRS2|PARK2|PDJ
Transcripts	ENSG00000185345
Virus	HTLV1
Gene Type	protein-coding
HPA Location Info	Nuclear speckles;Cytosol;
Membrane Info	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Uniport_ID	O60260
HGNC ID	HGNC:8607
OMIM ID	602544
Summary	The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6013601	chr6	5	13	1	19	View
6013604	chr6	7	12	0	19	View
6015962	chr6	12	1	0	13	View
6018888	chr6	7	1	0	8	View
6020066	chr6	7	0	0	7	View
6027314	chr6	2	0	0	2	View
6029141	chr6	0	1	0	1	View

Data ID	Experiment type	Sample number	Platform
GSE52244	Expression array	15	[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
C   GSE94732	Chip-seq	24	Illumina NextSeq 500 (Homo sapiens);illumina Genome Analyzer IIx (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE94732 - PRKN peak across samples

Peak Plot