Gene Name	PRMT5
Gene ID	10419
Gene Full Name	protein arginine methyltransferase 5
Gene Alias	HRMT1L5|HSL7|IBP72|JBP1|SKB1|SKB1Hs
Transcripts	ENSG00000100462
Virus	HEV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm, Cytosol;
Membrane Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	O14744
HGNC ID	HGNC:10894
OMIM ID	604045
Summary	This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	37276230	R458K	ORF1	ORF1	Cell line	I T	View

Data ID	Experiment type	Sample number	Platform
GSE262469	RNA-seq	15	Illumina NovaSeq 6000 (Homo sapiens)
GSE251924	RNA-seq	6	Illumina NovaSeq 6000 (Homo sapiens)
GSE274780	RNA-seq	12	Illumina NextSeq 500 (Homo sapiens)