Gene Name	RIGI
Gene ID	23586
Gene Full Name	RNA sensor RIG-I
Gene Alias	DDX58|RIG-I|RIG1|RLR-1|SGMRT2
Transcripts	ENSG00000107201
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Plasma membrane, Cytosol;
Membrane Info	Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	O95786
HGNC ID	HGNC:19102
OMIM ID	609631
Summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	18353943	R312A	VP35	VP35	Cell line	G I T	View
2	16698997	K309A	VP35	VP35	Cell line	G T	View
3	16698997	R312A	VP35	VP35	Cell line	G T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)