Gene Name	SIRT1
Gene ID	23411
Gene Full Name	sirtuin 1
Gene Alias	SIR2|SIR2L1|SIR2alpha
Transcripts	ENSG00000096717
Virus	EBOV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;Nucleoli fibrillar center, Mitochondria, Cytosol;
Membrane Info	Enzymes, Metabolic proteins, Predicted intracellular proteins
Uniport_ID	Q96EB6
HGNC ID	HGNC:14929
OMIM ID	604479
Summary	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	40288648	E619K	NP	NP	Cell line	D R S T	View

Data ID	Experiment type	Sample number	Platform
GSE96590	RNA-seq	20	Illumina HiSeq 1000 (Homo sapiens)
GSE80131	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)