| 24524846 |
22059 |
Trp53
|
Hormone |
Using the up-regulated genes, a total of 29 pathways were mapped; among them, 7 pathways changed significantly: the MAPK signaling pathway, the B-cell receptor signaling pathway, the T-cell receptor signaling pathway, the Toll-like receptor signaling pathway, the circadian rhythm, the C21-steroid hormone metabolism, and the p53 signaling pathway (Table 1). |
| 25963796 |
312670 |
Adipor2
|
Hormone |
Low-frequency EA induced estrous-cycle changes, decreased high levels of circulating luteinizing hormone (LH) and the LH/follicle-stimulating hormone (FSH) ratio, decreased high ovarian gene expression of adiponectin receptor 2, and increased expression of adiponectin receptor 2 protein and phosphorylation of ERK1/2. |
| 25963796 |
50689 |
Mapk3
|
Hormone |
Low-frequency EA induced estrous-cycle changes, decreased high levels of circulating luteinizing hormone (LH) and the LH/follicle-stimulating hormone (FSH) ratio, decreased high ovarian gene expression of adiponectin receptor 2, and increased expression of adiponectin receptor 2 protein and phosphorylation of ERK1/2. |
| 25963796 |
116590 |
Mapk1
|
Hormone |
Low-frequency EA induced estrous-cycle changes, decreased high levels of circulating luteinizing hormone (LH) and the LH/follicle-stimulating hormone (FSH) ratio, decreased high ovarian gene expression of adiponectin receptor 2, and increased expression of adiponectin receptor 2 protein and phosphorylation of ERK1/2. |
| 28299842 |
29316 |
Adora2b
|
Hormone |
Furthermore, EA-MSC cells expressed several growth hormones, hormone receptors and members of their signaling pathways (FGF5, BDNF, HTR2A, ADORA2B, and RLN) (Supplementary Tables S1 and S3). |
| 28299842 |
24225 |
Bdnf
|
Hormone |
Furthermore, EA-MSC cells expressed several growth hormones, hormone receptors and members of their signaling pathways (FGF5, BDNF, HTR2A, ADORA2B, and RLN) (Supplementary Tables S1 and S3). |
| 28299842 |
60662 |
Fgf5
|
Hormone |
Furthermore, EA-MSC cells expressed several growth hormones, hormone receptors and members of their signaling pathways (FGF5, BDNF, HTR2A, ADORA2B, and RLN) (Supplementary Tables S1 and S3). |
| 28299842 |
29595 |
Htr2a
|
Hormone |
Furthermore, EA-MSC cells expressed several growth hormones, hormone receptors and members of their signaling pathways (FGF5, BDNF, HTR2A, ADORA2B, and RLN) (Supplementary Tables S1 and S3). |
| 28806763 |
78240 |
Cst11
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
69362 |
Cst12
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
319579 |
Defb20
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
654459 |
Defb25
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
545475 |
Defb28
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
432867 |
Defb48
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
14780 |
Gpx5
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
78076 |
Lcn8
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
77704 |
Lcn9
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 28806763 |
20850 |
Stat5a
|
Hormone |
Gene ontology (GO) annotation indicated that the up-regulated genes in the hypothalamus of the Stat5NKO mice were mainly expressed in the extracellular region, basement membrane, plasma lipoprotein particle, and cytosol (Fig 2A); and these genes were significantly enriched in 140 biological processes, which were functionally clustered to extracellular matrix organization, response to hormone and insulin stimulus, lipid and saccharide metabolic process, fat cell differentiation, and positive regulation of adaptive and innate immune responses. |
| 28806763 |
20850 |
Stat5a
|
Hormone |
Among these genes (Fig 4E), FPKM values of 7 genes, which are associated with immune system and the response to hormone (AY761185, Cst11, Defb20, Defb28, Defb48, Lcn8, Lcn9) were decreased to zero by the deletion of central Stat5, whereas EA treatment reversed their expression levels, and the other 13 genes, such as Gpx5, 9230104L09Rik, Cst12, and Defb25, appeared in the top 40 down-regulated gene list of the Stat5NKO mice (S7 Table). |
| 30030752 |
18742 |
Pitx3
|
Hormone |
Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice. |
| 30030752 |
110312 |
Pmch
|
Hormone |
A transcriptome analysis of the hypothalamus revealed pro-melanin-concentrating hormone (Pmch) gene was highly expressed in acupuncture-treated mouse from ak/ak model of LID as well as 6-OHDA model of LID. |
| 35484628 |
80906 |
Kcnip2
|
Hormone |
Since neurohormones modulated ion channel function and expression, which led to arrhythmia, the transcript levels of Scn5A, KChIP2 and Kcne1 were detected by qPCR, and the results showed that acupuncture tended to increase Scn5A and KChIP2 but decrease Kcne1 expression levels (Fig. |
| 35484628 |
16509 |
Kcne1
|
Hormone |
Since neurohormones modulated ion channel function and expression, which led to arrhythmia, the transcript levels of Scn5A, KChIP2 and Kcne1 were detected by qPCR, and the results showed that acupuncture tended to increase Scn5A and KChIP2 but decrease Kcne1 expression levels (Fig. |
| 35484628 |
20271 |
Scn5a
|
Hormone |
Since neurohormones modulated ion channel function and expression, which led to arrhythmia, the transcript levels of Scn5A, KChIP2 and Kcne1 were detected by qPCR, and the results showed that acupuncture tended to increase Scn5A and KChIP2 but decrease Kcne1 expression levels (Fig. |
| 22337865 |
25149 |
Esr2
|
Hormone |
The mRNA expression of the steroid hormone receptors Esr2, Pgr and Kiss1r was lower in the manual group than in the control animals. |
| 22337865 |
78976 |
Kiss1r
|
Hormone |
The mRNA expression of the steroid hormone receptors Esr2, Pgr and Kiss1r was lower in the manual group than in the control animals. |
| 22337865 |
25154 |
Pgr
|
Hormone |
The mRNA expression of the steroid hormone receptors Esr2, Pgr and Kiss1r was lower in the manual group than in the control animals. |
| 23386059 |
24604 |
Npy
|
Hormone |
Finally, EA effect on peripheral and adrenal SNS hormones (norepinephrine (NE) and neuropeptide Y (NPY) respectively) was examined, with no significant difference noted in adrenal tyrosine hydroxylase or circulating NE in any of the groups. |
| 25206591 |
24664 |
Pomc
|
Hormone |
Concomitantly, upregulation of plasma cortisol, beta-endorphin and adrenocorticotropic hormone levels, and increased expression of hypothalamic intracellular protein kinase A, were found. |
| 25206591 |
25636 |
Prkaca
|
Hormone |
Concomitantly, upregulation of plasma cortisol, beta-endorphin and adrenocorticotropic hormone levels, and increased expression of hypothalamic intracellular protein kinase A, were found. |
| 25302705 |
25569 |
Trh
|
Hormone |
Trh gene encodes a member of the thyrotropin-releasing hormone family. |
| 25302705 |
25569 |
Trh
|
Hormone |
A previous study has shown that thyrotropin-releasing hormone receptor (TRHR) gene participates in the etiopathogenesis of essential hypertension, but the direct function of Trh on I/R injury is still unknown. |
| 25302705 |
25570 |
Trhr
|
Hormone |
A previous study has shown that thyrotropin-releasing hormone receptor (TRHR) gene participates in the etiopathogenesis of essential hypertension, but the direct function of Trh on I/R injury is still unknown. |
| 25887143 |
25305 |
Cort
|
Hormone |
The endpoints of measurement include corticosterone (CORT) level in peripheral blood, the expressions of corticotrophin releasing hormone (CRH) and glucocorticoid receptor (GR) protein in PVN and the animal behavioral performance. |
| 25887143 |
81648 |
Crh
|
Hormone |
The endpoints of measurement include corticosterone (CORT) level in peripheral blood, the expressions of corticotrophin releasing hormone (CRH) and glucocorticoid receptor (GR) protein in PVN and the animal behavioral performance. |
| 25887143 |
24413 |
Nr3c1
|
Hormone |
The endpoints of measurement include corticosterone (CORT) level in peripheral blood, the expressions of corticotrophin releasing hormone (CRH) and glucocorticoid receptor (GR) protein in PVN and the animal behavioral performance. |
| 26773866 |
81648 |
Crh
|
Hormone |
Hypothalamic corticotropin-releasing hormone (CRH) mRNA, plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) were estimated as indices of HPA axis activity. |
| 27179524 |
24413 |
Nr3c1
|
Hormone |
Concomitant EA application blocked nicotine-induced changes in lung morphology, lung Peroxisome Proliferator-Activated Receptor gamma and Wingless-int signaling, two key lung developmental signaling pathways, hypothalamic pituitary adrenal axis (hypothalamic corticotropic releasing hormone and lung glucocorticoid receptor levels), and plasma beta-endorphin levels. |
| 27179524 |
25664 |
Pparg
|
Hormone |
Concomitant EA application blocked nicotine-induced changes in lung morphology, lung Peroxisome Proliferator-Activated Receptor gamma and Wingless-int signaling, two key lung developmental signaling pathways, hypothalamic pituitary adrenal axis (hypothalamic corticotropic releasing hormone and lung glucocorticoid receptor levels), and plasma beta-endorphin levels. |
| 27179524 |
|
|
Hormone |
Concomitant EA application blocked nicotine-induced changes in lung morphology, lung Peroxisome Proliferator-Activated Receptor gamma and Wingless-int signaling, two key lung developmental signaling pathways, hypothalamic pituitary adrenal axis (hypothalamic corticotropic releasing hormone and lung glucocorticoid receptor levels), and plasma beta-endorphin levels. |
| 28761425 |
108348108 |
Hspa1b
|
Hormone |
Specifically, electroacupuncture lowered the peak levels of adrenocorticotrophic hormone and heat shock protein 70. |
| 34757591 |
24952 |
Gcg
|
Hormone |
GLP-1 is a peptide hormone secreted from enteroendocrine L-cells into the hepatic portal circulation in response to ingestion of nutrients. |
| 34757591 |
25608 |
Lep
|
Hormone |
Leptin, a hormone secreted from adipose tissue, plays a key role in energy balance and feeding behavior through neuronal regulation. |
| 37435647 |
24664 |
Pomc
|
Hormone |
In this study, a rat model of IBS was established by cold-restraint comprehensive stresses for 15 days, and it was found that the levels of corticotropin-releasing hormone (CRH), corticosterone (CORT), and adrenocorticotropic hormone (ACTH) in the peripheral serum were increased; the visceral sensitivity was enhanced; and the intestinal motility was accelerated, specifically, there was an enhancement in the discharge frequency of neurons in the paraventricular nucleus (PVN). |
| 37435647 |
24664 |
Pomc
|
Hormone |
Our results showed that combined with the serum changes in corticotropin-releasing hormone (CRH), corticosterone (CORT), and adrenocorticotropic hormone (ACTH), the improvement of IBS by EA was related to them. |
| 37435647 |
81648 |
Crh
|
Hormone |
In addition, EA could reduce the excitability of CRH neurons and the expression of corticotropin-releasing hormone receptor 1 (CRHR1) and corticotropin-releasing hormone receptor 2 (CRHR2) in PVN. |
| 37435647 |
81648 |
Crh
|
Hormone |
In this study, a rat model of IBS was established by cold-restraint comprehensive stresses for 15 days, and it was found that the levels of corticotropin-releasing hormone (CRH), corticosterone (CORT), and adrenocorticotropic hormone (ACTH) in the peripheral serum were increased; the visceral sensitivity was enhanced; and the intestinal motility was accelerated, specifically, there was an enhancement in the discharge frequency of neurons in the paraventricular nucleus (PVN). |
| 37435647 |
81648 |
Crh
|
Hormone |
Our results showed that combined with the serum changes in corticotropin-releasing hormone (CRH), corticosterone (CORT), and adrenocorticotropic hormone (ACTH), the improvement of IBS by EA was related to them. |
| 37435647 |
58959 |
Crhr1
|
Hormone |
In addition, EA could reduce the excitability of CRH neurons and the expression of corticotropin-releasing hormone receptor 1 (CRHR1) and corticotropin-releasing hormone receptor 2 (CRHR2) in PVN. |
| 37435647 |
64680 |
Crhr2
|
Hormone |
In addition, EA could reduce the excitability of CRH neurons and the expression of corticotropin-releasing hormone receptor 1 (CRHR1) and corticotropin-releasing hormone receptor 2 (CRHR2) in PVN. |
| 35704659 |
84022 |
Ghsr
|
Hormone |
Co-expression of kisspeptin and GHSR, and co-expression of gonadotrophin releasing hormone(GnRH) and NPY2R were observed in ARC. |
| 35704659 |
25194 |
Gnrh1
|
Hormone |
Co-expression of kisspeptin and GHSR, and co-expression of gonadotrophin releasing hormone(GnRH) and NPY2R were observed in ARC. |
| 35704659 |
289023 |
Kiss1
|
Hormone |
Co-expression of kisspeptin and GHSR, and co-expression of gonadotrophin releasing hormone(GnRH) and NPY2R were observed in ARC. |
| 35704659 |
66024 |
Npy2r
|
Hormone |
Co-expression of kisspeptin and GHSR, and co-expression of gonadotrophin releasing hormone(GnRH) and NPY2R were observed in ARC. |
| 33666871 |
24498 |
Il6
|
Hormone |
After 21 days of administration, the rat blood samples were collected for detecting the reproductive hormonal levels [luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2), progesterone (P), testosterone (T)] and inflammatory factors (visfatin, IL-6) analysis. |
| 33666871 |
297508 |
Nampt
|
Hormone |
After 21 days of administration, the rat blood samples were collected for detecting the reproductive hormonal levels [luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2), progesterone (P), testosterone (T)] and inflammatory factors (visfatin, IL-6) analysis. |
| 37303036 |
25378 |
Amh
|
Hormone |
Ovarian morphology was observed by HE staining, and sex hormone and AMH levels were detected by ELISA. |
| 37303036 |
500717 |
Meg3
|
Hormone |
Silencing of MEG3 attenuated sex hormone dysregulation and ovarian histopathological changes in PCOS rats and promoted follicle cell development and maturation. |
| 37303036 |
500717 |
Meg3
|
Hormone |
Silencing of MEG3 ameliorates abnormal sex hormone expression and ovarian histopathological changes in PCOS rats and promotes follicle cell development and maturation |
| 38178681 |
24185 |
Akt1
|
Hormone |
We measured changes in the ovarian indexes, the number of follicles at all levels, the serum levels of sex hormones and immune factors, the expression levels of phosphoinositide 3-kinase (PI3K), AKT, p-AKT, and caspase-3, and the changes in the proportions of splenic T cell subtypes, including T-helper 17 (Th17), Tc17, regulatory T (Treg), CD4+, and CD8+ cells. |
| 38178681 |
24185 |
Akt1
|
Hormone |
The regulation of sex hormone levels and immune function in rats may be attributed to the adjustment of the mRNA and proteins levels of PI3K, AKT, and caspase-3 in the PI3K/AKT signaling pathway, which leads to an improvement in the immune function of DOR rats. |
| 38178681 |
25402 |
Casp3
|
Hormone |
We measured changes in the ovarian indexes, the number of follicles at all levels, the serum levels of sex hormones and immune factors, the expression levels of phosphoinositide 3-kinase (PI3K), AKT, p-AKT, and caspase-3, and the changes in the proportions of splenic T cell subtypes, including T-helper 17 (Th17), Tc17, regulatory T (Treg), CD4+, and CD8+ cells. |
| 38178681 |
25402 |
Casp3
|
Hormone |
The regulation of sex hormone levels and immune function in rats may be attributed to the adjustment of the mRNA and proteins levels of PI3K, AKT, and caspase-3 in the PI3K/AKT signaling pathway, which leads to an improvement in the immune function of DOR rats. |
| 38178681 |
24932 |
Cd4
|
Hormone |
We measured changes in the ovarian indexes, the number of follicles at all levels, the serum levels of sex hormones and immune factors, the expression levels of phosphoinositide 3-kinase (PI3K), AKT, p-AKT, and caspase-3, and the changes in the proportions of splenic T cell subtypes, including T-helper 17 (Th17), Tc17, regulatory T (Treg), CD4+, and CD8+ cells. |
| 38178681 |
170911 |
Pik3ca
|
Hormone |
The regulation of sex hormone levels and immune function in rats may be attributed to the adjustment of the mRNA and proteins levels of PI3K, AKT, and caspase-3 in the PI3K/AKT signaling pathway, which leads to an improvement in the immune function of DOR rats. |
| 36655632 |
114215 |
Insl3
|
Hormone |
In addition, there was a significant increase in the Johnsen scores, seminiferous tubule diameters, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone, proliferation indices, and sex hormone-binding globulin (SHBG) and insulin-like peptide 3 (INSL3) immunoreactivities. |
| 36655632 |
24775 |
Shbg
|
Hormone |
In addition, there was a significant increase in the Johnsen scores, seminiferous tubule diameters, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone, proliferation indices, and sex hormone-binding globulin (SHBG) and insulin-like peptide 3 (INSL3) immunoreactivities. |
| 34886711 |
81648 |
Crh
|
Hormone |
The expression of corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH) and the glucocorticoid receptor (GR) was detected in local cutaneous tissues at the site of ST36 and LI4 by immunohistochemical staining. |
| 34886711 |
24413 |
Nr3c1
|
Hormone |
The expression of corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH) and the glucocorticoid receptor (GR) was detected in local cutaneous tissues at the site of ST36 and LI4 by immunohistochemical staining. |
| 34886711 |
24664 |
Pomc
|
Hormone |
The expression of corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH) and the glucocorticoid receptor (GR) was detected in local cutaneous tissues at the site of ST36 and LI4 by immunohistochemical staining. |
| 29785197 |
81648 |
Crh
|
Hormone |
In addition, the level of endocrine hormone CRH was upregulated after MA (0.88 +- 0.06 pg/ml). |
| 29785197 |
81503 |
Cxcl1
|
Hormone |
As shown in Figure 5, in the serum, the level of cytokine GRO/KC was upregulated and endocrine hormone PRL was downregulated after MA (515.95 +- 137.45 pg/ml, 6125.71 +- 4661.44 pg/ml, resp.). |
| 8736578 |
314322 |
Fos
|
Hormone |
No c-fos expression occurred in pituitary cells immunoreactive for growth hormone, prolactin, luteinizing hormone, or thyrotropin-stimulating hormone. |
| 8736578 |
81668 |
Gnrhr
|
Hormone |
No c-fos expression occurred in pituitary cells immunoreactive for growth hormone, prolactin, luteinizing hormone, or thyrotropin-stimulating hormone. |
| 8736578 |
24683 |
Prl
|
Hormone |
No c-fos expression occurred in pituitary cells immunoreactive for growth hormone, prolactin, luteinizing hormone, or thyrotropin-stimulating hormone. |
| 9048220 |
|
|
Hormone |
The effects of acupuncture-like stimulation of the abdomen and a hindlimb on the secretion rates of adrenal medullary catecholamine hormones (adrenaline and noradrenaline) and adrenal sympathetic efferent nerve activity were studied using urethane-anesthetized rats. |
| 19419550 |
79248 |
Abca2
|
Hormone |
The genes involved in the classification were: MGP, Abca2, and Sult1a1, which demonstrated that the transportation and production of steroid hormone may be regulated by acupuncture in the EAR phase of asthma at the level of transcription. |
| 19419550 |
83783 |
Sult1a1
|
Hormone |
The genes involved in the classification were: MGP, Abca2, and Sult1a1, which demonstrated that the transportation and production of steroid hormone may be regulated by acupuncture in the EAR phase of asthma at the level of transcription. |
