| 23499955 |
21991 |
Tpi1
|
Metabolism |
Glycometabolism disorder induced by triose phosphate isomerase (TPI) is closely related to Alzheimer's disease (AD). |
| 23499955 |
21991 |
Tpi1
|
Metabolism |
These findings suggested that the learning and memory deterioration of SAMP8 with aging might be associated with the lower TPI activity and that acupuncture could improve the cognitive impairment by increasing TPI activity, thus correcting the abnormal glycolysis metabolism and maintaining the brain homeostasis and internal environment. |
| 24524846 |
22059 |
Trp53
|
Metabolism |
Using the up-regulated genes, a total of 29 pathways were mapped; among them, 7 pathways changed significantly: the MAPK signaling pathway, the B-cell receptor signaling pathway, the T-cell receptor signaling pathway, the Toll-like receptor signaling pathway, the circadian rhythm, the C21-steroid hormone metabolism, and the p53 signaling pathway (Table 1). |
| 25983633 |
103142 |
Rdh9
|
Metabolism |
Widespread Rdh9 function in steroid or retinoid metabolism begins mid-embryogenesis, and may be an important link between neuroactive steroids and neurodegenerative disorders. |
| 25983633 |
216343 |
Tph2
|
Metabolism |
Tph2 was involved in tryptophan metabolism and serotonergic synapse at significant levels. |
| 28806763 |
12865 |
Cox7a1
|
Metabolism |
Additionally, 4 up-regulated genes (Ucp1, Cox7a1, Trfr2 and Ptgr1) as a result of loss of Stat5 in the CNS were also up-regulated by EA treatment, especially the gene encoding UCP1 (uncoupling protein1), which is involved in energy metabolism. |
| 28806763 |
19013 |
Ppara
|
Metabolism |
KEGG pathway analysis showed that EA down-regulated 370 genes were enriched in 16 pathways, including substance metabolism-especially lipid metabolism-such as PPAR signaling, adipocytokine signaling, fatty acid metabolism, insulin signaling, and glycerophopholipid metabolism. |
| 28806763 |
19013 |
Ppara
|
Metabolism |
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis confirmed that these up-regulated Differentially Expressed Genes (DEGs) belonged to extracellular matrix (ECM)-receptor interaction, complement and coagulation cascades, PPAR (Peroxisome Proliferator Activated Receptor) signaling pathway, adipocytokine signaling pathway, insulin signaling pathway, and several substance metabolism, which are closely related to lipids metabolism (Fig 2B). |
| 28806763 |
19013 |
Ppara
|
Metabolism |
KEGG pathway analysis suggested that these up-regulated genes were enriched in obesity-related pathways, including glycolysis, TCA (Tricarboxylic acid) cycle, fructose and mannose metabolism, PPAR signaling pathway, steroid biosynthesis, and fatty acid biosynthesis (Fig 2E). |
| 28806763 |
19013 |
Ppara
|
Metabolism |
leukocyte transendothelial migration), PPAR signaling pathway, O-glycan biosynthesis, and drug metabolism (Fig 2F). |
| 28806763 |
19013 |
Ppara
|
Metabolism |
KEGG analysis showed that they mainly participated in glycerophospholiplid metabolism, glycerolipid metabolism, PPAR signaling pathway, and ether lipid metabolism, which contributed to lipid metabolism (Fig 3D). |
| 28806763 |
67103 |
Ptgr1
|
Metabolism |
Additionally, 4 up-regulated genes (Ucp1, Cox7a1, Trfr2 and Ptgr1) as a result of loss of Stat5 in the CNS were also up-regulated by EA treatment, especially the gene encoding UCP1 (uncoupling protein1), which is involved in energy metabolism. |
| 28806763 |
20850 |
Stat5a
|
Metabolism |
EA treatment improved energy metabolism and cold tolerance in the Stat5NKO obese mice |
| 28806763 |
20850 |
Stat5a
|
Metabolism |
From the above analysis, we observed that a large number of genes and functional pathways involved in lipid metabolism, adipogenesis, insulin signaling, and immune system were dependent on the STAT5 molecule in the CNS. |
| 28806763 |
20850 |
Stat5a
|
Metabolism |
To investigate the extent to which central STAT5 can affect peripheral energy metabolism and adipogenesis, we further measured gene profiling in the Epi-WAT. |
| 28806763 |
20850 |
Stat5a
|
Metabolism |
Additionally, 4 up-regulated genes (Ucp1, Cox7a1, Trfr2 and Ptgr1) as a result of loss of Stat5 in the CNS were also up-regulated by EA treatment, especially the gene encoding UCP1 (uncoupling protein1), which is involved in energy metabolism. |
| 28806763 |
50765 |
Tfr2
|
Metabolism |
Additionally, 4 up-regulated genes (Ucp1, Cox7a1, Trfr2 and Ptgr1) as a result of loss of Stat5 in the CNS were also up-regulated by EA treatment, especially the gene encoding UCP1 (uncoupling protein1), which is involved in energy metabolism. |
| 28806763 |
22227 |
Ucp1
|
Metabolism |
Additionally, 4 up-regulated genes (Ucp1, Cox7a1, Trfr2 and Ptgr1) as a result of loss of Stat5 in the CNS were also up-regulated by EA treatment, especially the gene encoding UCP1 (uncoupling protein1), which is involved in energy metabolism. |
| 29980225 |
12064 |
Bdnf
|
Metabolism |
N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. |
| 29980225 |
12064 |
Bdnf
|
Metabolism |
EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. |
| 29980225 |
12064 |
Bdnf
|
Metabolism |
These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice. |
| 29980225 |
18212 |
Ntrk2
|
Metabolism |
N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. |
| 29980225 |
18212 |
Ntrk2
|
Metabolism |
EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. |
| 30843424 |
11820 |
App
|
Metabolism |
RESULTS: We found that, compared with the untreated SAMP8 group, donepezil, manual acupuncture, and combined therapy with donepezil and manual acupuncture all improved spatial learning and memory ability, the level of glucose metabolism in the brain, and the content of Abeta amyloid in the cortex. |
| 31835339 |
19013 |
Ppara
|
Metabolism |
Peroxisome proliferator-activated receptors (PPARs) are primary modulators in the metabolism of fatty acids in the liver and include PPARalpha, PPARbeta/delta, and PPARgamma. |
| 31835339 |
19015 |
Ppard
|
Metabolism |
Peroxisome proliferator-activated receptors (PPARs) are primary modulators in the metabolism of fatty acids in the liver and include PPARalpha, PPARbeta/delta, and PPARgamma. |
| 31835339 |
19016 |
Pparg
|
Metabolism |
Peroxisome proliferator-activated receptors (PPARs) are primary modulators in the metabolism of fatty acids in the liver and include PPARalpha, PPARbeta/delta, and PPARgamma. |
| 31835339 |
20787 |
Srebf1
|
Metabolism |
However, the expression of transcription factor sterol regulatory element binding protein 1 (SREBP1), an important transcriptional protein that regulates lipid synthesis with a well-studied function in lipid metabolism, was significantly lower in the AG livers than in the NG livers (p < 0.05, n = 7), while that of SREBP2, which primarily regulates cholesterol biosynthesis, showed no significant difference between the two groups (Figure 4B). |
| 31835339 |
20788 |
Srebf2
|
Metabolism |
However, the expression of transcription factor sterol regulatory element binding protein 1 (SREBP1), an important transcriptional protein that regulates lipid synthesis with a well-studied function in lipid metabolism, was significantly lower in the AG livers than in the NG livers (p < 0.05, n = 7), while that of SREBP2, which primarily regulates cholesterol biosynthesis, showed no significant difference between the two groups (Figure 4B). |
| 33607237 |
16846 |
Lep
|
Metabolism |
Then, lipidomics was applied to investigate the effects of acupuncture on lipid metabolism and analyze leptin signals in the brain and changes of immune markers. |
| 33607237 |
16846 |
Lep
|
Metabolism |
In conclusion, these results show that AP acupuncture treatment effectively alleviated the depression-like behavior, affected immune responses, and altered hepatic lipid metabolism through the attenuation of leptin insensitivity. |
| 34981123 |
19013 |
Ppara
|
Metabolism |
We performed a bioinformatics analysis, which revealed that DEPs enriched in the KEGG pathway after acupuncture treatment were mainly involved in the PPAR signaling pathway, fatty acid biosynthesis, fatty acid metabolism, fatty acid elongation, fat digestion and absorption. |
| 22583765 |
171163 |
Slc6a13
|
Metabolism |
Boulet et al. [1] found a large increase in Glu and GABA levels in the striatum and a marked decrease in DA levels and metabolism. |
| 26037401 |
25027 |
Slc16a1
|
Metabolism |
SIGNIFICANCE: Our results suggest that the EA treatments activated lactate metabolism in the resident astrocytes around the ischemic area and up-regulated the expression of MCT1 in these astrocytes which facilitated the transfer of intracellular lactate to extracellular domain to be utilized by injured neurons to improve the neurological deficit. |
| 28358020 |
24329 |
Egfr
|
Metabolism |
EGFR has been verified to play a regulatory role in hepatocyte proliferation and plasma lipid metabolism in adult male mice. |
| 28358020 |
24329 |
Egfr
|
Metabolism |
The data indicated that the cellular over-proliferation in gastric mucosa during the progression of CAG increased the activation of the EGFR signaling pathways, leading to upregulation the lipid metabolism. |
| 28358020 |
364837 |
Gypc
|
Metabolism |
Besides, metabolites that play roles in the integrity of cellular membrane and tissue osmolarity as PC, GPC, myo-inositol, taurine and betaine were also regulated by electro-acupuncture treatment while metabolites related to brain energy metabolism such as creatine, lactate, alanine and leucine showed no significant improvement. |
| 34646336 |
25608 |
Lep
|
Metabolism |
On basis of these results, it was found that acupuncture could boost fat metabolism and weight loss by inhibiting the production of leptin and prostaglandin E. |
| 34757591 |
24505 |
Ins1
|
Metabolism |
Markers of carbohydrate metabolism, such as glucose and insulin, are strongly associated with health problems in HFD-STZ rats. |
| 37096024 |
29277 |
Cyp2c11
|
Metabolism |
The Hk3, Cyp2c11, Pah, and Tph1 genes, which are all involved in the endogenous metabolism, were up-regulated in the VPA_acupuncture group. |
| 37096024 |
252931 |
Cyp3a18
|
Metabolism |
Tat played a role in enhancing viral replication; Cyp3a18, Cyp4a3, Cyp4a1, and Cyp4a2 were involved in endogenous metabolism. |
| 37096024 |
50549 |
Cyp4a1
|
Metabolism |
Tat played a role in enhancing viral replication; Cyp3a18, Cyp4a3, Cyp4a1, and Cyp4a2 were involved in endogenous metabolism. |
| 37096024 |
24306 |
Cyp4a2
|
Metabolism |
Tat played a role in enhancing viral replication; Cyp3a18, Cyp4a3, Cyp4a1, and Cyp4a2 were involved in endogenous metabolism. |
| 37096024 |
298423 |
Cyp4a3
|
Metabolism |
Tat played a role in enhancing viral replication; Cyp3a18, Cyp4a3, Cyp4a1, and Cyp4a2 were involved in endogenous metabolism. |
| 37096024 |
25060 |
Hk3
|
Metabolism |
The Hk3, Cyp2c11, Pah, and Tph1 genes, which are all involved in the endogenous metabolism, were up-regulated in the VPA_acupuncture group. |
| 37096024 |
24616 |
Pah
|
Metabolism |
The Hk3, Cyp2c11, Pah, and Tph1 genes, which are all involved in the endogenous metabolism, were up-regulated in the VPA_acupuncture group. |
| 37096024 |
24813 |
Tat
|
Metabolism |
Tat played a role in enhancing viral replication; Cyp3a18, Cyp4a3, Cyp4a1, and Cyp4a2 were involved in endogenous metabolism. |
| 37096024 |
24848 |
Tph1
|
Metabolism |
The Hk3, Cyp2c11, Pah, and Tph1 genes, which are all involved in the endogenous metabolism, were up-regulated in the VPA_acupuncture group. |
| 32249904 |
56718 |
Mtor
|
Metabolism |
As shown in Figure 4B, in the warm acupuncture-treated group, when compared with the control groups, proteins with differential levels were enriched in the KEGG pathways of ribosome, RNA transportation, chemical carcinogenesis, protein processing in endoplasmic reticulum, 5-hydroxytryptamine synapse, adhering junctions, inflammatory mediator regulation of TRP channels, platinum resistance, influenza A, Hippo signaling, glycolysis, apelin signaling, mTOR signaling, olfactory transduction, of vascular smooth muscle contraction, insulin resistance, protein binding, Rapl signaling and central carbon metabolism in cancer (Supplementary Table S7). |
| 30906419 |
24505 |
Ins1
|
Metabolism |
The top 10 significantly signaling pathways were, respectively, associated with metabolic pathways, a mitogen-activated protein kinases (MAPK) signaling pathway, insulin signaling pathway, focal adhesion, endocytosis, apoptosis, glutathione metabolism, Hippo signaling pathway, and inositol phosphate metabolism, and protein processing in endoplasmic reticulum was identified. |
| 29972006 |
29423 |
Gap43
|
Metabolism |
The level of nerve growth associated protein (GAP-43) and energy metabolism-related protein monocarboxylate transporter protien 1(MCT 1) were detected by Western blot. |
| 29972006 |
29423 |
Gap43
|
Metabolism |
CONCLUSION: Acupuncture combined with NGF could improve the neurobehavioral ability of cerebral palsy infant rats, inhibit the nerve cell apoptosis and improve the brain tissue injure and energy metabolism by up-regulating the expressions of GAP-43 and MCT 1. |
| 29972006 |
25027 |
Slc16a1
|
Metabolism |
The level of nerve growth associated protein (GAP-43) and energy metabolism-related protein monocarboxylate transporter protien 1(MCT 1) were detected by Western blot. |
| 29972006 |
25027 |
Slc16a1
|
Metabolism |
CONCLUSION: Acupuncture combined with NGF could improve the neurobehavioral ability of cerebral palsy infant rats, inhibit the nerve cell apoptosis and improve the brain tissue injure and energy metabolism by up-regulating the expressions of GAP-43 and MCT 1. |
| 29972006 |
310738 |
Ngf
|
Metabolism |
[Study of acupuncture combined with rat nerve growth factor on neurobehavioral ability of cerebral palsy infant rats and its brain tissue growth and metabolism associated proteins]. |
| 29972006 |
310738 |
Ngf
|
Metabolism |
OBJECTIVE: To study the effects of acupuncture combined with rat nerve growth factor (NGF) on the cerebral palsy infant rats and the proteins which associated with growth, apoptosis and metabolism. |
| 29972006 |
310738 |
Ngf
|
Metabolism |
CONCLUSION: Acupuncture combined with NGF could improve the neurobehavioral ability of cerebral palsy infant rats, inhibit the nerve cell apoptosis and improve the brain tissue injure and energy metabolism by up-regulating the expressions of GAP-43 and MCT 1. |
| 35928244 |
306574 |
Slc25a15
|
Metabolism |
Therefore, results from the evaluation of mitochondria and mitochondrial energy metabolism genes revealed that Slc25a15 is a key gene in MA. |
| 35928244 |
306574 |
Slc25a15
|
Metabolism |
Results from immunohistostaining revealed the distribution of Slc25a15, a key gene of the mitochondria and mitochondrial energy metabolism. |
| 32967614 |
84475 |
Cxcr3
|
Metabolism |
Moreover, it significantly down-regulated P2X4 and OX42 expression along with the reduced levels of inflammatory factors (CXCR3, TNF-alpha, IL-1beta, IL-6), GSP and lipid metabolisms in the spinal cord of the DPN rats. |
| 32967614 |
24494 |
Il1b
|
Metabolism |
Moreover, it significantly down-regulated P2X4 and OX42 expression along with the reduced levels of inflammatory factors (CXCR3, TNF-alpha, IL-1beta, IL-6), GSP and lipid metabolisms in the spinal cord of the DPN rats. |
| 32967614 |
24498 |
Il6
|
Metabolism |
Moreover, it significantly down-regulated P2X4 and OX42 expression along with the reduced levels of inflammatory factors (CXCR3, TNF-alpha, IL-1beta, IL-6), GSP and lipid metabolisms in the spinal cord of the DPN rats. |
| 32967614 |
24835 |
Tnf
|
Metabolism |
Moreover, it significantly down-regulated P2X4 and OX42 expression along with the reduced levels of inflammatory factors (CXCR3, TNF-alpha, IL-1beta, IL-6), GSP and lipid metabolisms in the spinal cord of the DPN rats. |
