Gene symbol: Defb48

Also known as: Defb42; EG432867

Organism: Mus musculus

Summary: Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to bacterium. Predicted to be active in extracellular space. Orthologous to human DEFB109C (defensin beta 109C). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 432867 Ensembl:ENSMUSG00000075574 AllianceGenome:MGI:3646223


GO Annotation


Category Term ID Term description
Process GO:0006935 Chemotaxis
Process GO:0006950 Response to stress
Process GO:0006952 Defense response
Process GO:0007154 Cell communication
Process GO:0007165 Signal transduction
Process GO:0009605 Response to external stimulus
Process GO:0009607 Response to biotic stimulus
Process GO:0009617 Response to bacterium
Process GO:0009987 Cellular process
Process GO:0016477 Cell migration
Process GO:0023052 Signaling
Process GO:0040011 Locomotion
Process GO:0042221 Response to chemical
Process GO:0042330 Taxis
Process GO:0042742 Defense response to bacterium
Process GO:0043207 Response to external biotic stimulus
Process GO:0044419 Biological process involved in interspecies interaction between organisms
Process GO:0048870 Cell motility
Process GO:0050789 Regulation of biological process
Process GO:0050794 Regulation of cellular process
Process GO:0050896 Response to stimulus
Process GO:0050918 Positive chemotaxis
Process GO:0051707 Response to other organism
Process GO:0051716 Cellular response to stimulus
Process GO:0060326 Cell chemotaxis
Process GO:0065007 Biological regulation
Process GO:0070887 Cellular response to chemical stimulus
Process GO:0098542 Defense response to other organism
Component GO:0005576 Extracellular region
Component GO:0005615 Extracellular space
Component GO:0110165 Cellular anatomical entity
Function GO:0001664 G protein-coupled receptor binding
Function GO:0005102 Signaling receptor binding
Function GO:0005126 Cytokine receptor binding
Function GO:0005488 Binding
Function GO:0005515 Protein binding
Function GO:0030545 Signaling receptor regulator activity
Function GO:0030546 Signaling receptor activator activity
Function GO:0031731 CCR6 chemokine receptor binding
Function GO:0042056 Chemoattractant activity
Function GO:0042379 Chemokine receptor binding
Function GO:0048018 Receptor ligand activity
Function GO:0048020 CCR chemokine receptor binding
Function GO:0098772 Molecular function regulator activity

Pathway annotation


Category Term ID Term description
RCTM MMU-1461957 Beta defensins
RCTM MMU-1461973 Defensins
RCTM MMU-168249 Innate Immune System
RCTM MMU-168256 Immune System
RCTM MMU-6803157 Antimicrobial peptides

Expression profile of Defb48 in omics data



ID GSE109165
Title Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway
Organism Mus musculus
GSM Sample info Characteristics Value
GSM2934457 WT_Naive_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 0.0
GSM2934458 WT_Naive_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 0.0
GSM2934459 WT_Naive_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 1.0
GSM2934460 WT_Naive_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 0.0
GSM2934461 KO_Naive_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 0.0
GSM2934462 KO_Naive_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 0.0
GSM2934463 KO_Naive_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 0.0
GSM2934464 KO_Naive_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 0.0
GSM2934465 WT_Morphine_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 0.0
GSM2934466 WT_Morphine_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 1.0
GSM2934467 WT_Morphine_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 0.0
GSM2934468 WT_Morphine_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 0.0
GSM2934469 KO_Morphine_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 0.0
GSM2934470 KO_Morphine_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 0.0
GSM2934471 KO_Morphine_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 0.0
GSM2934472 KO_Morphine_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 0.0

ID GSE125076
Title A mouse model of acute post-surgical pain
Organism Mus musculus
GSM Sample info Characteristics Value
GSM3562188 DRG_WT_sham_1 strain: C57BL/6 gender: male age: 8 weeks treatment: naïve 0.0
GSM3562189 DRG_WT_sham_2 strain: C57BL/6 gender: male age: 8 weeks treatment: naïve 0.0
GSM3562190 DRG_WT_sham_3 strain: C57BL/6 gender: male age: 8 weeks treatment: naïve 0.0
GSM3562191 DRG_WT_PSP_1 strain: C57BL/6 gender: male age: 8 weeks treatment: 24h post surgery 0.0
GSM3562192 DRG_WT_PSP_2 strain: C57BL/6 gender: male age: 8 weeks treatment: 24h post surgery 0.0
GSM3562193 DRG_WT_PSP_3 strain: C57BL/6 gender: male age: 8 weeks treatment: 24h post surgery 0.0

ID GSE138802
Title Mesocorticolimbic circuit mechanisms underlying the effects of ketamine on dopamine: a translational imaging study
Organism Mus musculus
GSM Sample info Characteristics Value
GSM4119733 PLc_1_Sal strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Saline 0.0
GSM4119734 PLc_10_Sal strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Saline 0.0
GSM4119735 PLc_6_Sal strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Saline 0.0
GSM4119736 PLc_5_Ket strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Ketamine 0.0
GSM4119737 PLc_3_Ket strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Ketamine 0.0
GSM4119738 PLc_9_Ket strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Ketamine 0.0

ID GSE163828
Title Regulation of electro-acupuncture(EA) and astragalus membranaceus (AM) on genes in bone marrow
Organism Mus musculus
GSM Sample info Characteristics Value
GSM4988039 BH190126-1_control tissue: bone marrow 5.38
GSM4988040 BH190126-1_treatment of astragalus membranaceus tissue: bone marrow 4.63
GSM4988041 BH190126-1_cisplatin tissue: bone marrow 5.35
GSM4988042 BH190126-1_treatment of electro-acupuncture tissue: bone marrow 5.08

ID GSE223541
Title Oxycodone withdrawal induces HDAC1/2-dependent transcriptional maladaptations in the reward pathway in a murine model of peripheral nerve injury
Organism Mus musculus
GSM Sample info Characteristics Value
GSM6958536 B1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sa 0.0
GSM6958537 C1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958538 F1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958539 H1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0
GSM6958540 B2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 0.0
GSM6958541 C2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958542 F2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 1.0
GSM6958543 H2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0
GSM6958544 B3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 0.0
GSM6958545 C3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 1.0
GSM6958546 F3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958547 H3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0
GSM6958548 B4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 0.0
GSM6958549 C4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958550 F4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958551 H4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0

ID GSE24829
Title Gene expression data from striatal regions of MPTP-intoxicated mouse brain by acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM611081 Control mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: Control 3.6206
GSM611082 Control mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: Control 3.4707
GSM611083 MPTP-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP-treated 3.64413
GSM611084 MPTP-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP-treated 3.81112
GSM611085 MPTP and acupoints acupuncture-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.70036
GSM611086 MPTP and acupoints acupuncture-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.5107
GSM611087 MPTP and nonacupoints acupuncture-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 4.21396
GSM611088 MPTP and nonacupoints acupuncture-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 3.83369

ID GSE24830
Title Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM611089 Control mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: Control 3.12733
GSM611090 Control mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: Control 3.09892
GSM611091 MPTP-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP-treated 2.94538
GSM611092 MPTP-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP-treated 3.00081
GSM611093 MPTP and acupoints acupuncture-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 2.91378
GSM611094 MPTP and acupoints acupuncture-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.09974
GSM611095 MPTP and nonacupoints acupuncture-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 2.68249
GSM611096 MPTP and nonacupoints acupuncture-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 2.54621

ID GSE24838
Title Gene expression data from brain striatal and spinal cord regions of MPTP-intoxicated mouse following acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM611081 Control mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: Control 3.6206
GSM611082 Control mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: Control 3.4707
GSM611083 MPTP-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP-treated 3.64413
GSM611084 MPTP-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP-treated 3.81112
GSM611085 MPTP and acupoints acupuncture-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.70036
GSM611086 MPTP and acupoints acupuncture-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.5107
GSM611087 MPTP and nonacupoints acupuncture-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 4.21396
GSM611088 MPTP and nonacupoints acupuncture-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 3.83369
GSM611089 Control mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: Control 3.12733
GSM611090 Control mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: Control 3.09892
GSM611091 MPTP-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP-treated 2.94538
GSM611092 MPTP-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP-treated 3.00081
GSM611093 MPTP and acupoints acupuncture-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 2.91378
GSM611094 MPTP and acupoints acupuncture-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.09974
GSM611095 MPTP and nonacupoints acupuncture-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 2.68249
GSM611096 MPTP and nonacupoints acupuncture-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 2.54621

ID GSE26364
Title Gene expression changes in alpha GABA receptors in the mice brains after prolonged ketamine administration
Organism Mus musculus
GSM Sample info Characteristics Value
GSM647254 Saline PFC 1 strain: ICR tissue: prefrontal cortex Sex: female 3.05972
GSM647255 Saline PFC 2 strain: ICR tissue: prefrontal cortex Sex: female 3.03563
GSM647256 Ketamine PFC 1 strain: ICR tissue: prefrontal cortex Sex: female 2.61257
GSM647257 Ketamine PFC 2 strain: ICR tissue: prefrontal cortex Sex: female 3.03931

ID GSE35138
Title Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM862520 Control mouse 1 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.31975
GSM862521 Control mouse 2 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.22297
GSM862522 MPTP-treated mouse 1 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.18571
GSM862523 MPTP-treated mouse 2 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.34209
GSM862524 MPTP and acupoints acupuncture-treated mouse 1 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.8116
GSM862525 MPTP and acupoints acupuncture-treated mouse 2 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.30028
GSM862526 MPTP and nonacupoints acupuncture-treated mouse 1 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.0422
GSM862527 MPTP and nonacupoints acupuncture-treated mouse 2 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.52425

ID GSE48293
Title Gene expression data from substantia nigral regions of MPTP-intoxicated mouse brain by acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM1174263 Control mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: Control 5.9149
GSM1174264 Control mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: Control 6.91569
GSM1174265 MPTP-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP-treated 7.31885
GSM1174266 MPTP-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP-treated 7.30807
GSM1174267 MPTP and acupoints acupuncture-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 7.17475
GSM1174268 MPTP and acupoints acupuncture-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 7.43164
GSM1174269 MPTP and nonacupoints acupuncture-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 7.05159
GSM1174270 MPTP and nonacupoints acupuncture-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 7.01754